PEA15 and HTRA2

Number of citations of the paper that reports this interaction (PMID 15328349)
10

Data Source:
HPRD (in vitro)

		PEA15	HTRA2
Gene Name		phosphoprotein enriched in astrocytes 15	HtrA serine peptidase 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Associated Complex	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding
	Biological Process	DNA Damage Checkpoint Transport Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ABCD4 AK9 AKT1 CAMK2G CASP8 FADD HTRA2 L1CAM LUC7L2 MAPK1 MAPK3 PANK4 PDPK1 PLD1 PLD2 PRKCA RPS6KA3 TERF2IP	37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP
Entrez ID		8682	27429
HPRD ID		04579	05919
Ensembl ID		ENSG00000162734	ENSG00000115317
Uniprot IDs		B1AKZ3 B1AKZ4 B1AKZ5 Q15121	O43464
PDB IDs		4IZ5 4IZA	1LCY 2PZD
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response Positive Regulation Of Immune System Process Immune Response Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stress Toll-like Receptor 4 Signaling Pathway Response To Temperature Stimulus Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Epidermal Growth Factor Response To Growth Factor Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Programmed Cell Death Cell Activation Toll-like Receptor Signaling Pathway Response To Heat Response To Cytokine Cell Death Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Immune System Process Activation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Labyrinthine Layer Development Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Heat Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Cellular Response To Organic Substance Cellular Response To Mechanical Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Immune Response Platelet Activation	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway
Tagcloud ?		abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified	betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer
Tagcloud (Difference) ?		abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified	betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer
Tagcloud (Intersection) ?