PEA15 and TALDO1

Number of citations of the paper that reports this interaction (PubMedID 24710276)
50

Data Source:
BioGRID (two hybrid)

		PEA15	TALDO1
Description		proliferation and apoptosis adaptor protein 15	transaldolase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Transaldolase Activity Protein Binding Transferase Activity Carbohydrate Binding Monosaccharide Binding
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Glyceraldehyde-3-phosphate Metabolic Process
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade	Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P Pentose phosphate pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation NFE2L2 regulates pentose phosphate pathway genes
Drugs
Diseases
GWAS			Keratoconus ( 33649486) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	8 interacting genes: CEBPA LSM8 PEA15 TERF1 TERF2 TERF2IP UBE3A ZHX1
Entrez ID		8682	6888
HPRD ID		04579	03640
Ensembl ID		ENSG00000162734	ENSG00000177156
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	A0A140VK56 P37837
PDB IDs		4IZ5 4IZA 6P6B 6P6C	1F05
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway	Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Telomerase Activity Protection From Non-homologous End Joining At Telomere Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding DNA Biosynthetic Process Telomere Maintenance Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Maintenance In Response To DNA Damage Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Nucleoplasm Positive Regulation Of DNA Metabolic Process Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Chromosome Organization Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex
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