PEA15 and OSBPL1A

Number of citations of the paper that reports this interaction (PubMedID 24710276)
50

Data Source:
BioGRID (two hybrid)

		PEA15	OSBPL1A
Description		proliferation and apoptosis adaptor protein 15	oxysterol binding protein like 1A
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Cytoplasm Endosome Late Endosome Cytosol Plasma Membrane Organelle Membrane Contact Site Extracellular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Sterol Transfer Activity
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Bile Acid Biosynthetic Process Lipid Transport Cholesterol Metabolic Process Sterol Transport Vesicle-mediated Transport
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade	Synthesis of bile acids and bile salts MHC class II antigen presentation
Drugs
Diseases
GWAS			Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Neutrophil count ( 32888494) Osteoporosis-related phenotypes ( 20548944) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 25483131) White blood cell count ( 32888494)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	7 interacting genes: BAALC DYRK1A MEOX2 PEA15 RSPH1 TIAM1 TSC22D2
Entrez ID		8682	114876
HPRD ID		04579	09472
Ensembl ID		ENSG00000162734	ENSG00000141447
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	B0YJ56 B3KU11 Q6GSK5 Q9BXW6
PDB IDs		4IZ5 4IZA 6P6B 6P6C	5ZM5 5ZM6 5ZM7 6IYB 6TQS 8ZQ3
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway
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