PEA15 and MTIF3

Number of citations of the paper that reports this interaction (PubMedID 24710276)
50

Data Source:
BioGRID (two hybrid)

		PEA15	MTIF3
Description		proliferation and apoptosis adaptor protein 15	mitochondrial translational initiation factor 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Mitochondrion
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosome Binding Ribosomal Small Subunit Binding
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Translation Translational Initiation Ribosome Disassembly Mitochondrial Translational Initiation
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade	Mitochondrial translation initiation
Drugs
Diseases
GWAS			Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Body mass index ( 20935630 25673413 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate change in renal transplantation (recipient effect) ( 30920136) Night sleep phenotypes ( 27126917) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	88 interacting genes: ADGRE2 APOD BCL2L1 BMP10 BPIFA1 BRICD5 CABP7 CD47 CDIPT CDS2 CGRRF1 CLDND2 CLEC7A CMTM5 COL4A5 COQ8A CTXN3 CXCL9 CYBC1 CYP4F2 EPGN FBXO7 FETUB FXYD3 FXYD6-FXYD2 HSFX1 HSFX2 HTATIP2 INSIG2 ITGB2 JAGN1 LAPTM4B LAT LDLR LHFPL5 MAPK1 MGST3 MRFAP1 MS4A1 NAT8 NDRG4 ORMDL1 ORMDL2 ORMDL3 PAXIP1 PEA15 PLN PLP1 PRH1 RPRM SCD SELENOK SERP1 SERP2 SERTM1 SIAH1 SNX2 SPANXN2 STARD4 STATH STRIT1 STX3 STX6 THBD THSD7B TMED8 TMEM109 TMEM11 TMEM128 TMEM147 TMEM176A TMEM218 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM97 TRARG1 TSPAN33 TUFM UNC50 VAMP4 VEZT VKORC1L1 YIPF6 ZDHHC15 ZNF202
Entrez ID		8682	219402
HPRD ID		04579	17609
Ensembl ID		ENSG00000162734	ENSG00000122033
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	Q9H2K0
PDB IDs		4IZ5 4IZA 6P6B 6P6C	6NEQ 6NF8 6RW4 6RW5 7P2E 8QRM
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex Regulation Of Transport Regulation Of Lipid Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Synaptic Vesicle To Endosome Fusion Regulation Of Cellular Localization Granulocyte Migration Regulation Of Cholesterol Metabolic Process Regulation Of Membrane Lipid Metabolic Process Respiratory Burst After Phagocytosis Negative Regulation Of Lipid Metabolic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Neutrophil Migration Cholesterol Import Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Cholesterol Metabolic Process Myeloid Leukocyte Migration
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