PEA15 and CEP120

Number of citations of the paper that reports this interaction (PubMedID 24710276)
50

Data Source:
BioGRID (two hybrid)

		PEA15	CEP120
Description		proliferation and apoptosis adaptor protein 15	centrosomal protein 120
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Cytoplasm Centrosome Centriole Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Microtubule Cytoskeleton Organization Centrosome Cycle Cell Population Proliferation Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Astral Microtubule Organization Regulation Of Protein Localization Regulation Of Microtubule-based Process Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Process Positive Regulation Of Organelle Assembly Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Coronary artery disease ( 29212778) Height ( 20881960 25429064 31562340) Multisite chronic pain ( 31194737) Obesity (extreme) ( 30677029) Pulse pressure ( 30578418) Virologic severity in Herpes simplex virus type 2 infection ( 29535370) Waist circumference ( 26785701)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	2 interacting genes: PEA15 STAT3
Entrez ID		8682	153241
HPRD ID		04579	08769
Ensembl ID		ENSG00000162734	ENSG00000168944
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	A0A6Q8PF83 A0A6Q8PH95 B4DLH5 Q8N960
PDB IDs		4IZ5 4IZA 6P6B 6P6C	4ICW 4ICX 6FLJ 6FLK
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway	Regulation Of Hydrogen Peroxide Metabolic Process Interleukin-10-mediated Signaling Pathway RNA Sequestering Activity Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Negative Regulation Of Primary MiRNA Processing Cellular Response To Leptin Stimulus Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Inflammatory Response To Wounding Inflammatory Response To Wounding Interleukin-2-mediated Signaling Pathway Negative Regulation Of Hydrogen Peroxide Metabolic Process Nuclear Glucocorticoid Receptor Binding Postsynapse To Nucleus Signaling Pathway Regulation Of Skeletal Muscle Satellite Cell Proliferation Interleukin-9-mediated Signaling Pathway Negative Regulation Of Neuron Migration Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Interleukin-11-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Retinal Rod Cell Differentiation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Regulatory NcRNA Processing Sexual Reproduction Interleukin-23-mediated Signaling Pathway Cellular Response To Interleukin-17 Positive Regulation Of ATP Biosynthetic Process Regulation Of Skeletal Muscle Cell Proliferation Camera-type Eye Photoreceptor Cell Differentiation Interleukin-15-mediated Signaling Pathway Negative Regulation Of MiRNA Processing T-helper 17 Type Immune Response Negative Regulation Of Inflammatory Response To Wounding Primary MiRNA Binding Interleukin-6-mediated Signaling Pathway Leptin-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation T-helper 17 Cell Lineage Commitment Radial Glial Cell Differentiation CCR5 Chemokine Receptor Binding Negative Regulation Of D-glucose Import Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Glycolytic Process Photoreceptor Cell Differentiation Eye Photoreceptor Cell Differentiation T-helper Cell Lineage Commitment Response To Leptin
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