PEA15 and PANK4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PEA15	PANK4
Description		proliferation and apoptosis adaptor protein 15	pantothenate kinase 4 (inactive)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Pantothenate Kinase Activity ATP Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Coenzyme A Biosynthetic Process Pantothenate Metabolic Process
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade	Vitamin B5 (pantothenate) metabolism
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	2 interacting genes: CDK20 PEA15
Entrez ID		8682	55229
HPRD ID		04579	07313
Ensembl ID		ENSG00000162734	ENSG00000157881
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	Q9NVE7
PDB IDs		4IZ5 4IZA 6P6B 6P6C
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway	Floor Plate Formation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Signal Transduction Negative Regulation Of D-glucose Import Negative Regulation Of Cell Communication Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Microtubule Associated Complex Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of D-glucose Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Signaling Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Tube Closure Regulation Of Smoothened Signaling Pathway Protein Localization To Cilium Embryonic Skeletal System Development Regulation Of Protein Maturation Neural Tube Closure Camera-type Eye Development Negative Regulation Of Smoothened Signaling Pathway Roof Of Mouth Development Cyclin-dependent Protein Serine/threonine Kinase Activity Embryonic Brain Development Embryonic Camera-type Eye Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
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