PEA15 and PPP4R3A

Number of citations of the paper that reports this interaction (PubMedID 24710276)
50

Data Source:
BioGRID (two hybrid)

		PEA15	PPP4R3A
Description		proliferation and apoptosis adaptor protein 15	protein phosphatase 4 regulatory subunit 3A
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein Phosphatase 4 Complex
	Molecular Function	Protein Binding	Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Gluconeogenesis DNA Damage Response Positive Regulation Of Gluconeogenesis Regulation Of Double-strand Break Repair
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Decline in glucose metabolism in posterior cingulate cortex ( 29130521)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	6 interacting genes: CASK CDK1 CEBPA MAPK14 PEA15 RNF113A
Entrez ID		8682	55671
HPRD ID		04579	11176
Ensembl ID		ENSG00000162734	ENSG00000100796
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	Q6IN85 Q8N6W1
PDB IDs		4IZ5 4IZA 6P6B 6P6C	6R8I
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway	Positive Regulation Of Heart Growth Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Intracellular Signaling Cassette MAPK Cascade Positive Regulation Of Protein Import Into Nucleus Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Organ Growth Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Heart Growth Protein Serine/threonine Kinase Activity Positive Regulation Of Fat Cell Differentiation Energy Homeostasis Regulation Of D-glucose Import Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Organ Growth Protein Kinase Activity Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Cellular Response To Tumor Necrosis Factor Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Regulation Of Nucleocytoplasmic Transport Small Molecule Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Tumor Necrosis Factor Response To Vitamin B2 C/EBP Complex SnoRNA Splicing Cellular Response To Stress Positive Regulation Of Intracellular Transport Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Regulation Of Intracellular Protein Transport Regulation Of Transport Kinase Activity Cyclin-dependent Protein Kinase Activity Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Nuclear Matrix Myeloid Leukocyte Differentiation Regulation Of Synaptic Membrane Adhesion Regulation Of Cell Population Proliferation
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