PEA15 and SON

Number of citations of the paper that reports this interaction (PubMedID 24710276)
50

Data Source:
BioGRID (two hybrid)

		PEA15	SON
Description		proliferation and apoptosis adaptor protein 15	SON DNA and RNA binding protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex	Nucleus Nuclear Speck
	Molecular Function	Protein Binding	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding
	Biological Process	MAPK Cascade Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Microtubule Cytoskeleton Organization Mitotic Cytokinesis MRNA Processing RNA Splicing Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Cell Cycle
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Heel bone mineral density x serum urate levels interaction ( 34046847) Psoriasis ( 25854761)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	9 interacting genes: CLIP4 MAGEA6 PEA15 PRPF40A SNIP1 TRIP6 VHL YWHAB YWHAG
Entrez ID		8682	6651
HPRD ID		04579	01678
Ensembl ID		ENSG00000162734	ENSG00000159140
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	J3QSZ5 P18583 Q6ZRV7
PDB IDs		4IZ5 4IZA 6P6B 6P6C	7CIQ 7CIR 7CIS 7DYN
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Protein Serine Kinase Activity Cytosol Cytoplasm Protein Serine/threonine Kinase Activity Response To Epidermal Growth Factor Positive Regulation Of Macrophage Differentiation Regulation Of Golgi Organization Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Interleukin-34-mediated Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Migration Response To Peptide Response To Cytokine Regulation Of Cellular Response To Stress Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Execution Phase Of Apoptosis Death Effector Domain Binding Regulation Of Macrophage Differentiation Regulation Of Golgi Inheritance Neural Crest Cell Development ATP Binding Positive Regulation Of Cell Motility Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Stem Cell Development Ripoptosome CD95 Death-inducing Signaling Complex Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway RNA (guanine-N7)-methylation Death-inducing Signaling Complex Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Apoptotic Process Protein Phosphorylation Protein Autophosphorylation Response To Tumor Necrosis Factor Vascular Endothelial Cell Response To Laminar Fluid Shear Stress TRAIL-activated Apoptotic Signaling Pathway Outer Ear Morphogenesis ERBB3 Signaling Pathway	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Phosphatase Inhibitor Activity Protein Sequestering Activity
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