PEA15 and ABCD4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PEA15	ABCD4
Gene Name		phosphoprotein enriched in astrocytes 15	ATP-binding cassette, sub-family D (ALD), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Associated Complex	Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane ATP-binding Cassette (ABC) Transporter Complex
	Molecular Function	Protein Binding	ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	DNA Damage Checkpoint Transport Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cobalamin Metabolic Process Small Molecule Metabolic Process Transmembrane Transport
Pathways			Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Orphan transporters Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ABCD4 AK9 AKT1 CAMK2G CASP8 FADD HTRA2 L1CAM LUC7L2 MAPK1 MAPK3 PANK4 PDPK1 PLD1 PLD2 PRKCA RPS6KA3 TERF2IP	4 interactors: DLEU1 PEA15 SARAF XRCC6
Entrez ID		8682	5826
HPRD ID		04579	04446
Ensembl ID		ENSG00000162734	ENSG00000119688
Uniprot IDs		B1AKZ3 B1AKZ4 B1AKZ5 Q15121	F8W7M4 O14678
PDB IDs		4IZ5 4IZA
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response Positive Regulation Of Immune System Process Immune Response Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stress Toll-like Receptor 4 Signaling Pathway Response To Temperature Stimulus Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Epidermal Growth Factor Response To Growth Factor Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Programmed Cell Death Cell Activation Toll-like Receptor Signaling Pathway Response To Heat Response To Cytokine Cell Death Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Immune System Process Activation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Labyrinthine Layer Development Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Heat Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Cellular Response To Organic Substance Cellular Response To Mechanical Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Immune Response Platelet Activation	Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Negative Regulation Of Glucose Import Cellular Response To Salt Stress DNA Ligation Negative Regulation Of Glucose Transport Regulation Of Store-operated Calcium Entry Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors V(D)J Recombination Cellular Response To DNA Damage Stimulus Cellular Response To Osmotic Stress Response To X-ray Response To Salt Stress Response To Morphine Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Ionizing Radiation
Tagcloud ?		abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified	b12 biophysical coa cofactor crosslinking detergent dilution homodimers impairing inactivating lmbd1 lmbrd1 lysosomal mals methionine methylmalonyl milieu mmachc mutase nanomolar plasmon protecting scattering sec solubilized spr vectorial vitamin whereby
Tagcloud (Difference) ?		abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified	b12 biophysical coa cofactor crosslinking detergent dilution homodimers impairing inactivating lmbd1 lmbrd1 lysosomal mals methionine methylmalonyl mmachc mutase nanomolar plasmon protecting scattering sec solubilized spr vectorial vitamin whereby
Tagcloud (Intersection) ?		milieu