EPHA2 and FZR1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		EPHA2	FZR1
Description		EPH receptor A2	fizzy and cell division cycle 20 related 1
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane Cell Projection Receptor Complex Tight Junction Anchoring Junction	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Cadherin Binding Molecular Function Activator Activity	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Skeletal System Development Angiogenesis Blood Vessel Development Vasculogenesis Osteoblast Differentiation Negative Regulation Of Cytokine Production Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Apoptotic Process Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Cell Migration Negative Regulation Of Angiogenesis Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Regulation Of Cell Adhesion Keratinocyte Differentiation Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Chemokine Production Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis CAMP Metabolic Process Symbiont Entry Into Host Cell Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Animal Organ Development Blood Vessel Morphogenesis Notochord Morphogenesis Cell Motility Defense Response To Gram-positive Bacterium Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Activation Of GTPase Activity Negative Regulation Of Lymphangiogenesis Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Bicellular Tight Junction Assembly Pericyte Cell Differentiation	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)	Red cell distribution width ( 32888494)
Interacting Genes		81 interacting genes: ABCB5 ACP1 AKT1 ANXA1 ARAF ARNT AURKA BECN1 CBL CBLC CCND2 CD44 CDC42 CDH5 CDK17 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLDN4 DUSP14 DUSP18 DUSP19 DUSP26 DUSP29 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR FZR1 GATAD1 GLIS2 GRB2 GRK2 GRM1 HGF HIF1A ILKAP KDELR2 KPNA3 LATS2 LSM7 MAP2K5 MAP2K6 MAPK14 MDM4 MET MSH2 MYC NF1 NF2 NFIC NUDT9 PIK3R1 PIK3R2 PPM1L PSME2 PTEN PTK2 PTPN11 PTPN7 PTPRR RASA1 RASSF1 RBL1 RELA RNF5 SHC1 SLA STK11 STYX TEAD2 TIAM1 TNFAIP1 TP53 TPTE TPTE2 UBE4A	95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10
Entrez ID		1969	51343
HPRD ID		01494	04687
Ensembl ID		ENSG00000142627	ENSG00000105325
Uniprot IDs		P29317	Q9UM11
PDB IDs		1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 5IA2 5IA3 5IA4 5IA5 5NJZ 5NK0 5NK1 5NK2 5NK3 5NK4 5NK5 5NK6 5NK7 5NK8 5NK9 5NKA 5NKB 5NKC 5NKD 5NKE 5NKF 5NKG 5NKH 5NKI 5NZ9 6B9L 6F7M 6F7N 6FNF 6FNG 6FNH 6HES 6HET 6HEU 6HEV 6HEW 6HEX 6HEY 6NJZ 6NK0 6NK1 6NK2 6NKP 6Q7B 6Q7C 6Q7D 6Q7E 6Q7F 6Q7G 6RW2 7B7N 7CZE 7CZF 7KJA 7KJB 7KJC 8BIN 8BIO 8BK0 8BM8 8BOC 8BOD 8BOF 8BOG 8BOH 8BOI 8BOK 8BOM 8QQY 8T9B 8TRS 8TRT 8TRV 8TV1 8TV5 8XPV	4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Phosphatase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Process Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Negative Regulation Of Programmed Cell Death Ephrin Receptor Binding Phosphotyrosine Residue Binding Negative Regulation Of Apoptotic Process Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Protein Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Protein Kinase Binding Positive Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Developmental Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Response To Radiation Response To UV Regulation Of Protein Localization To Nucleus Neurotrophin TRKA Receptor Binding Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Communication	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process
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