EPHA2 and CDC42

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		EPHA2	CDC42
Description		EPH receptor A2	cell division cycle 42
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane Cell Projection Receptor Complex Tight Junction Anchoring Junction	Golgi Membrane Storage Vacuole Cytoplasm Endoplasmic Reticulum Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Golgi Transport Complex Filopodium Dendrite Midbody Cell Leading Edge Leading Edge Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Neuronal Cell Body Apical Part Of Cell Phagocytic Vesicle Spindle Midzone Extracellular Exosome Cell Periphery Mitotic Spindle Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Cadherin Binding Molecular Function Activator Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding GBD Domain Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development Angiogenesis Blood Vessel Development Vasculogenesis Osteoblast Differentiation Negative Regulation Of Cytokine Production Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Apoptotic Process Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Cell Migration Negative Regulation Of Angiogenesis Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Regulation Of Cell Adhesion Keratinocyte Differentiation Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Chemokine Production Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis CAMP Metabolic Process Symbiont Entry Into Host Cell Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Animal Organ Development Blood Vessel Morphogenesis Notochord Morphogenesis Cell Motility Defense Response To Gram-positive Bacterium Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Activation Of GTPase Activity Negative Regulation Of Lymphangiogenesis Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Bicellular Tight Junction Assembly Pericyte Cell Differentiation	Heart Process Cardiac Conduction System Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endocytosis Phagocytosis, Engulfment Actin Filament Organization Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Nervous System Development Intracellular Protein Localization Anatomical Structure Morphogenesis Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Substantia Nigra Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Adherens Junction Organization Embryonic Heart Tube Development Establishment Or Maintenance Of Apical/basal Cell Polarity Dendritic Cell Migration Neuropilin Signaling Pathway Positive Regulation Of MAPK Cascade Host-mediated Perturbation Of Viral Process Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Positive Regulation Of Pinocytosis Neuron Fate Determination Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Nucleus Localization Establishment Of Localization In Cell Establishment Of Golgi Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Dendritic Spine Morphogenesis Cellular Response To Type II Interferon Organelle Transport Along Microtubule Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Postsynapse Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	GPVI-mediated activation cascade EGFR downregulation Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs		Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib Fostamatinib	Aminophosphonic acid-guanylate ester Guanosine-5'-Diphosphate
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)	Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Hip circumference adjusted for BMI ( 34021172) Immune response to smallpox vaccine (IL-6) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Uterine fibroids ( 30194396 31249589 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		81 interacting genes: ABCB5 ACP1 AKT1 ANXA1 ARAF ARNT AURKA BECN1 CBL CBLC CCND2 CD44 CDC42 CDH5 CDK17 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLDN4 DUSP14 DUSP18 DUSP19 DUSP26 DUSP29 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR FZR1 GATAD1 GLIS2 GRB2 GRK2 GRM1 HGF HIF1A ILKAP KDELR2 KPNA3 LATS2 LSM7 MAP2K5 MAP2K6 MAPK14 MDM4 MET MSH2 MYC NF1 NF2 NFIC NUDT9 PIK3R1 PIK3R2 PPM1L PSME2 PTEN PTK2 PTPN11 PTPN7 PTPRR RASA1 RASSF1 RBL1 RELA RNF5 SHC1 SLA STK11 STYX TEAD2 TIAM1 TNFAIP1 TP53 TPTE TPTE2 UBE4A	383 interacting genes: A2M AARS1 ACADM ACO1 ACO2 ACOT7 ACTR3 ADRM1 AGAP1 AGAP2 AHSG AKR1B1 ALDH18A1 ANAPC13 ANXA11 ANXA2 AP3D1 APEX1 APOH ARAP1 ARAP2 ARG1 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP26 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP40 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 ATP5F1C ATP5IF1 ATP5MF ATP5PD ATP6V1A BAIAP2 BCAP31 BCCIP BCL2L13 BCR BIRC2 BLMH BNIP2 BRD10 BTF3 BZW2 CALML5 CAPNS1 CAPZB CARHSP1 CASP14 CASP3 CASP7 CBLL1 CBX3 CCN1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC5L CDH1 CDKN2A CEBPA CFHR4 CGN CMPK1 CNBP CNOT1 COL1A1 COMT COPA COPE COPG1 CPN1 CRIP2 CSE1L CSN2 CSPG4 CTNNA1 DEF6 DEK DHFR DIAPH1 DIAPH2 DIAPH3 DNMBP DOCK7 DOCK8 DOCK9 DPYSL2 DSG1 DSP ECHS1 EDC4 EDF1 EEF1E1 EEF1G EHD2 EHD4 EIF2AK2 EIF3D EIF3F EIF5 EIF5B EPHA2 EPRS1 ERCC3 ERG28 ERICH6 ERRFI1 ETFA FAM13B FGD1 FGD2 FGD3 FGD4 FKBP10 FKBP1A FKBP3 FLNA FLNC FMN2 FMNL2 FNBP1 FNBP1L FNDC3B FTH1 G6PD GALNT2 GART GDI1 GIT2 GLS GMIP GNB1 GRB2 GRWD1 GSR GSTM5 H1-10 H1-5 H2BC13 HADH HADHB HDAC7 HDLBP HERC2 HLA-G HMGN1 HNRNPAB HNRNPUL2 HSD17B10 HYOU1 IARS1 IGF2BP1 IPO5 IQGAP1 IQGAP2 ITSN1 JPT2 KARS1 KAT5 KHDRBS1 KPNA2 KTN1 KYNU LARS1 LCK LGALS1 LGALS7 LONP1 LRIF1 LRP2 LYZ MAP2K3 MAP3K10 MAP3K11 MAP3K19 MAP3K4 MAP4 MAPRE1 MARCKSL1 MARK4 MASTL MATR3 MCF2L MCM3AP MCM6 MCM7 MDH1 MDK METAP2 MRM1 MRPL49 MSH2 MT-CO1 MTDH MUC12 MYO1C MYO6 MYO9A NAA15 NASP NCAPD2 NCF2 NEK6 NIBAN2 NOP2 NPLOC4 NQO1 NUDT21 NUP155 OCRL OLA1 OPHN1 P3H1 PABPC4 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PALLD PARD3 PARD6A PARD6B PARD6G PAXX PCM1 PCNP PDCD5 PDE6C PDE6D PGD PGGT1B PHAX PHB2 PHPT1 PICALM PIK3R1 PLD1 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PMS1 PPP2R1A PRDX3 PREX2 PRKCA PRKCG PRKCI PRKCZ PSAT1 PSIP1 PSMB1 PSMC5 PSMC6 PSMD11 PSMD12 PSMD3 PSME3 PXDN RAC2 RAP1GDS1 RARS1 RASGRF2 RBM8A RHOJ RIOK3 RO60 RPL22 RPL23 RPS15 RPS21 RPS6KB1 RRM1 S100A9 SDHA SEPTIN2 SERPINB1 SERPINB2 SERPINB3 SF1 SF3A2 SH3BGRL3 SH3D19 SLC16A3 SMC2 SNCA SNRNP70 SPATA13 SRGAP1 SRM SRP72 SRSF1 SSB SSX2IP ST13 STARD8 STAT1 STAU1 STMN2 SYNE1 TBC1D3F TBCA TCEAL3 TIAM1 TMED10 TMED9 TMOD3 TMX1 TNFRSF10B TNK2 TOR1AIP1 TP53 TPD52L2 TPM1 TRAF2 TRIM28 TRIM45 TRIM60 TRIO TRIP10 TRRAP TSFM TTC12 TUBB3 TXNL1 TYMS U2AF2 UBC UBE2L3 UBR1 UGDH UNC119 USP6 VARS1 VASP VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 XIAP XPO1 YARS1 YWHAH ZNF175 ZNF234 ZNF415 ZNF420 ZNF622
Entrez ID		1969	998
HPRD ID		01494	00309
Ensembl ID		ENSG00000142627	ENSG00000070831
Uniprot IDs		P29317	P60953
PDB IDs		1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 5IA2 5IA3 5IA4 5IA5 5NJZ 5NK0 5NK1 5NK2 5NK3 5NK4 5NK5 5NK6 5NK7 5NK8 5NK9 5NKA 5NKB 5NKC 5NKD 5NKE 5NKF 5NKG 5NKH 5NKI 5NZ9 6B9L 6F7M 6F7N 6FNF 6FNG 6FNH 6HES 6HET 6HEU 6HEV 6HEW 6HEX 6HEY 6NJZ 6NK0 6NK1 6NK2 6NKP 6Q7B 6Q7C 6Q7D 6Q7E 6Q7F 6Q7G 6RW2 7B7N 7CZE 7CZF 7KJA 7KJB 7KJC 8BIN 8BIO 8BK0 8BM8 8BOC 8BOD 8BOF 8BOG 8BOH 8BOI 8BOK 8BOM 8QQY 8T9B 8TRS 8TRT 8TRV 8TV1 8TV5 8XPV	1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR 4JS0 4YC7 4YDH 5CJP 5FI1 5HZK 5UPK 5UPL 6AJ4 6AJL 6SIU 6SUP 6TKY 6TKZ 7S0Y 8I5F
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Phosphatase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Process Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Negative Regulation Of Programmed Cell Death Ephrin Receptor Binding Phosphotyrosine Residue Binding Negative Regulation Of Apoptotic Process Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Protein Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Protein Kinase Binding Positive Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Developmental Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Response To Radiation Response To UV Regulation Of Protein Localization To Nucleus Neurotrophin TRKA Receptor Binding Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Communication	Cytosol Cytoplasm Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Regulation Of Intracellular Signal Transduction Small GTPase Binding Guanyl-nucleotide Exchange Factor Activity Actin Filament-based Process Small GTPase-mediated Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Lamellipodium Intracellular Signal Transduction Regulation Of Signal Transduction Cytoskeleton Organization RNA Binding Regulation Of Signaling Regulation Of Cell Communication Rho Protein Signal Transduction Extracellular Exosome Organelle Organization Cadherin Binding Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cell Projection Organization Cell Cortex PAR Polarity Complex Biological_process Regulation Of Actin Filament-based Process Ruffle Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Cellular Component Organization Protein Serine Kinase Activity Supramolecular Fiber Organization Anchoring Junction Regulation Of Protein Metabolic Process Actin Cytoskeleton Cellular Component Assembly Regulation Of Programmed Cell Death Regulation Of Actin Filament Organization Actin Binding Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell Morphogenesis Actin Filament Protein Serine/threonine Kinase Activity Regulation Of Rho Protein Signal Transduction
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