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EPHA2 and PIK3R2
Number of citations of the paper that reports this interaction (PubMedID
35384245
)
105
Data Source:
BioGRID
(proximity labelling technology, proximity labelling technology)
HPRD
(in vivo, two hybrid, in vitro)
EPHA2
PIK3R2
Description
EPH receptor A2
phosphoinositide-3-kinase regulatory subunit 2
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Lamellipodium
Leading Edge Membrane
Lamellipodium Membrane
Ruffle Membrane
Cell Projection
Receptor Complex
Tight Junction
Anchoring Junction
Nucleus
Cytosol
Focal Adhesion
Phosphatidylinositol 3-kinase Complex, Class IA
Molecular Function
Nucleotide Binding
Virus Receptor Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Ephrin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cadherin Binding
Molecular Function Activator Activity
Phosphotyrosine Residue Binding
GTPase Activator Activity
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Biological Process
Skeletal System Development
Angiogenesis
Blood Vessel Development
Vasculogenesis
Osteoblast Differentiation
Negative Regulation Of Cytokine Production
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Apoptotic Process
Response To Stress
Inflammatory Response
Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Lamellipodium Assembly
Notochord Formation
Cell Migration
Negative Regulation Of Angiogenesis
Neural Tube Development
Central Nervous System Neuron Differentiation
Cell Differentiation
Regulation Of Cell Adhesion
Keratinocyte Differentiation
Osteoclast Differentiation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Epithelial Cell Differentiation
Negative Regulation Of Chemokine Production
Mammary Gland Epithelial Cell Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Post-anal Tail Morphogenesis
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Angiogenesis
CAMP Metabolic Process
Symbiont Entry Into Host Cell
Bone Remodeling
Ephrin Receptor Signaling Pathway
Axial Mesoderm Formation
Animal Organ Development
Blood Vessel Morphogenesis
Notochord Morphogenesis
Cell Motility
Defense Response To Gram-positive Bacterium
Notochord Cell Development
Cell Chemotaxis
Branching Involved In Mammary Gland Duct Morphogenesis
Lens Fiber Cell Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Negative Regulation Of Lymphangiogenesis
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Bicellular Tight Junction Assembly
Pericyte Cell Differentiation
Intracellular Glucose Homeostasis
Immune Response
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Protein Transport
B Cell Differentiation
T Cell Differentiation
Regulation Of Actin Filament Polymerization
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Stress Fiber Assembly
Regulation Of Protein Localization To Plasma Membrane
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by ALK fusions and activated point mutants
Signaling by LTK in cancer
Signaling by LTK
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Co-stimulation by ICOS
Drugs
Dasatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Regorafenib
Fostamatinib
SF1126
Diseases
GWAS
Alanine aminotransferase levels (
33339817
33547301
34315874
)
Aspartate aminotransferase levels (
33547301
34315874
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Interacting Genes
81 interacting genes:
ABCB5
ACP1
AKT1
ANXA1
ARAF
ARNT
AURKA
BECN1
CBL
CBLC
CCND2
CD44
CDC42
CDH5
CDK17
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLDN4
DUSP14
DUSP18
DUSP19
DUSP26
DUSP29
EFNA1
EFNA2
EFNA3
EFNA4
EFNA5
EGFR
FZR1
GATAD1
GLIS2
GRB2
GRK2
GRM1
HGF
HIF1A
ILKAP
KDELR2
KPNA3
LATS2
LSM7
MAP2K5
MAP2K6
MAPK14
MDM4
MET
MSH2
MYC
NF1
NF2
NFIC
NUDT9
PIK3R1
PIK3R2
PPM1L
PSME2
PTEN
PTK2
PTPN11
PTPN7
PTPRR
RASA1
RASSF1
RBL1
RELA
RNF5
SHC1
SLA
STK11
STYX
TEAD2
TIAM1
TNFAIP1
TP53
TPTE
TPTE2
UBE4A
60 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
Entrez ID
1969
5296
HPRD ID
01494
04404
Ensembl ID
ENSG00000142627
ENSG00000105647
Uniprot IDs
P29317
O00459
PDB IDs
1MQB
2E8N
2K9Y
2KSO
2X10
2X11
3C8X
3CZU
3FL7
3HEI
3HPN
3KKA
3MBW
3MX0
3SKJ
4P2K
4PDO
4TRL
5EK7
5I9U
5I9V
5I9W
5I9X
5I9Y
5I9Z
5IA0
5IA1
5IA2
5IA3
5IA4
5IA5
5NJZ
5NK0
5NK1
5NK2
5NK3
5NK4
5NK5
5NK6
5NK7
5NK8
5NK9
5NKA
5NKB
5NKC
5NKD
5NKE
5NKF
5NKG
5NKH
5NKI
5NZ9
6B9L
6F7M
6F7N
6FNF
6FNG
6FNH
6HES
6HET
6HEU
6HEV
6HEW
6HEX
6HEY
6NJZ
6NK0
6NK1
6NK2
6NKP
6Q7B
6Q7C
6Q7D
6Q7E
6Q7F
6Q7G
6RW2
7B7N
7CZE
7CZF
7KJA
7KJB
7KJC
8BIN
8BIO
8BK0
8BM8
8BOC
8BOD
8BOF
8BOG
8BOH
8BOI
8BOK
8BOM
8QQY
8T9B
8TRS
8TRT
8TRV
8TV1
8TV5
8XPV
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
7RCH
7RNU
Enriched GO Terms of Interacting Partners
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Regulation Of Intracellular Signal Transduction
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Cell Communication
Regulation Of Signaling
Protein Tyrosine Phosphatase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Cycle Process
Intracellular Signal Transduction
Phosphoprotein Phosphatase Activity
Negative Regulation Of Programmed Cell Death
Ephrin Receptor Binding
Phosphotyrosine Residue Binding
Negative Regulation Of Apoptotic Process
Cell Differentiation
Ephrin Receptor Signaling Pathway
Regulation Of Mitotic Cell Cycle
Regulation Of Programmed Cell Death
Regulation Of MAPK Cascade
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Adhesion
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Cellular Developmental Process
Response To Growth Factor
Protein Dephosphorylation
Negative Regulation Of Intracellular Signal Transduction
Protein Kinase Binding
Positive Regulation Of Signal Transduction
Animal Organ Development
MAPK Cascade
Developmental Process
Cellular Response To Stress
Positive Regulation Of Intracellular Signal Transduction
Response To Radiation
Response To UV
Regulation Of Protein Localization To Nucleus
Neurotrophin TRKA Receptor Binding
Negative Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signal Transduction
Receptor Complex
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Cell Migration
Regulation Of Cell Motility
Intracellular Signal Transduction
Positive Regulation Of Cell Migration
Regulation Of Cell Population Proliferation
Regulation Of Developmental Process
Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Regulation Of Locomotion
Positive Regulation Of Locomotion
Kinase Activity
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Developmental Process
Peptidyl-tyrosine Phosphorylation
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Developmental Process
Cellular Response To Growth Factor Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Development
Cell Population Proliferation
Growth Factor Binding
Positive Regulation Of Epithelial Cell Proliferation
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Morphogenesis Of An Epithelium
ERBB Signaling Pathway
Tissue Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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