EPHA2 and NF1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		EPHA2	NF1
Description		EPH receptor A2	neurofibromin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane Cell Projection Receptor Complex Tight Junction Anchoring Junction	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Cadherin Binding Molecular Function Activator Activity	GTPase Activator Activity Protein Binding Lipid Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding
	Biological Process	Skeletal System Development Angiogenesis Blood Vessel Development Vasculogenesis Osteoblast Differentiation Negative Regulation Of Cytokine Production Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Apoptotic Process Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Cell Migration Negative Regulation Of Angiogenesis Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Regulation Of Cell Adhesion Keratinocyte Differentiation Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Chemokine Production Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis CAMP Metabolic Process Symbiont Entry Into Host Cell Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Animal Organ Development Blood Vessel Morphogenesis Notochord Morphogenesis Cell Motility Defense Response To Gram-positive Bacterium Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Activation Of GTPase Activity Negative Regulation Of Lymphangiogenesis Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Bicellular Tight Junction Assembly Pericyte Cell Differentiation	MAPK Cascade Angiogenesis Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Leukocyte Migration Protein Import Into Nucleus Apoptotic Process Cell Communication Ras Protein Signal Transduction Neurotransmitter Secretion Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Schwann Cell Proliferation Glial Cell Proliferation Schwann Cell Proliferation Schwann Cell Development Cell Migration Negative Regulation Of Angiogenesis Rac Protein Signal Transduction Spinal Cord Development Amygdala Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Osteoclast Differentiation Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Apoptotic Process Myeloid Cell Apoptotic Process Positive Regulation Of Myeloid Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Rac Protein Signal Transduction Schwann Cell Migration Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Astrocyte Differentiation Oligodendrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Hair Follicle Maturation Artery Morphogenesis Forebrain Morphogenesis Regulation Of Developmental Process Cognition Neuron Apoptotic Process Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Gamma-aminobutyric Acid Secretion, Neurotransmission Glutamate Secretion, Neurotransmission Regulation Of ERK1 And ERK2 Cascade Mast Cell Proliferation Negative Regulation Of Mast Cell Proliferation Leukocyte Apoptotic Process Stem Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Myeloid Leukocyte Migration Observational Learning Regulation Of Postsynapse Organization Negative Regulation Of Schwann Cell Migration Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants
Drugs		Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib Fostamatinib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)	Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 32499647 30297969)
Interacting Genes		81 interacting genes: ABCB5 ACP1 AKT1 ANXA1 ARAF ARNT AURKA BECN1 CBL CBLC CCND2 CD44 CDC42 CDH5 CDK17 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLDN4 DUSP14 DUSP18 DUSP19 DUSP26 DUSP29 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR FZR1 GATAD1 GLIS2 GRB2 GRK2 GRM1 HGF HIF1A ILKAP KDELR2 KPNA3 LATS2 LSM7 MAP2K5 MAP2K6 MAPK14 MDM4 MET MSH2 MYC NF1 NF2 NFIC NUDT9 PIK3R1 PIK3R2 PPM1L PSME2 PTEN PTK2 PTPN11 PTPN7 PTPRR RASA1 RASSF1 RBL1 RELA RNF5 SHC1 SLA STK11 STYX TEAD2 TIAM1 TNFAIP1 TP53 TPTE TPTE2 UBE4A	17 interacting genes: AKT1 APP CLK1 DNAJC7 EFS EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP
Entrez ID		1969	4763
HPRD ID		01494	01203
Ensembl ID		ENSG00000142627	ENSG00000196712
Uniprot IDs		P29317	P21359
PDB IDs		1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 5IA2 5IA3 5IA4 5IA5 5NJZ 5NK0 5NK1 5NK2 5NK3 5NK4 5NK5 5NK6 5NK7 5NK8 5NK9 5NKA 5NKB 5NKC 5NKD 5NKE 5NKF 5NKG 5NKH 5NKI 5NZ9 6B9L 6F7M 6F7N 6FNF 6FNG 6FNH 6HES 6HET 6HEU 6HEV 6HEW 6HEX 6HEY 6NJZ 6NK0 6NK1 6NK2 6NKP 6Q7B 6Q7C 6Q7D 6Q7E 6Q7F 6Q7G 6RW2 7B7N 7CZE 7CZF 7KJA 7KJB 7KJC 8BIN 8BIO 8BK0 8BM8 8BOC 8BOD 8BOF 8BOG 8BOH 8BOI 8BOK 8BOM 8QQY 8T9B 8TRS 8TRT 8TRV 8TV1 8TV5 8XPV	1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F 7MOC 7MP5 7MP6 7PGP 7PGQ 7PGR 7PGS 7PGT 7PGU 7R03 7R04 8E20 8EDL 8EDM 8EDN 8EDO
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Phosphatase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Process Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Negative Regulation Of Programmed Cell Death Ephrin Receptor Binding Phosphotyrosine Residue Binding Negative Regulation Of Apoptotic Process Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Protein Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Protein Kinase Binding Positive Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Developmental Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Response To Radiation Response To UV Regulation Of Protein Localization To Nucleus Neurotrophin TRKA Receptor Binding Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Communication	Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Neuronal Synaptic Plasticity Glial Cell Development Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Protein Kinase Activity Regulation Of Intracellular Signal Transduction Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Cellular Response To Oxygen-containing Compound Modulation Of Excitatory Postsynaptic Potential Regulation Of Protein Localization Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Glutamate Binding Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Protein Serine/threonine Kinase Activity Excitatory Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Positive Regulation Of Protein Localization Response To Radiation Insulin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Projection Assembly Positive Regulation Of Intracellular Signal Transduction Regulation Of Postsynaptic Membrane Potential Nucleotide Binding Schwann Cell Development Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Developmental Process Regulation Of Phosphorus Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation
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