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EPHA2 and CBL
Number of citations of the paper that reports this interaction (PubMedID
12496371
)
0
Data Source:
HPRD
(in vivo)
EPHA2
CBL
Description
EPH receptor A2
Cbl proto-oncogene
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Lamellipodium
Leading Edge Membrane
Lamellipodium Membrane
Ruffle Membrane
Cell Projection
Receptor Complex
Tight Junction
Anchoring Junction
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Membrane
Flotillin Complex
Axon
Growth Cone
Cell Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Virus Receptor Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Ephrin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cadherin Binding
Molecular Function Activator Activity
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
SH3 Domain Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Metal Ion Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Kinase Binding
Biological Process
Skeletal System Development
Angiogenesis
Blood Vessel Development
Vasculogenesis
Osteoblast Differentiation
Negative Regulation Of Cytokine Production
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Apoptotic Process
Response To Stress
Inflammatory Response
Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Lamellipodium Assembly
Notochord Formation
Cell Migration
Negative Regulation Of Angiogenesis
Neural Tube Development
Central Nervous System Neuron Differentiation
Cell Differentiation
Regulation Of Cell Adhesion
Keratinocyte Differentiation
Osteoclast Differentiation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Epithelial Cell Differentiation
Negative Regulation Of Chemokine Production
Mammary Gland Epithelial Cell Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Post-anal Tail Morphogenesis
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Angiogenesis
CAMP Metabolic Process
Symbiont Entry Into Host Cell
Bone Remodeling
Ephrin Receptor Signaling Pathway
Axial Mesoderm Formation
Animal Organ Development
Blood Vessel Morphogenesis
Notochord Morphogenesis
Cell Motility
Defense Response To Gram-positive Bacterium
Notochord Cell Development
Cell Chemotaxis
Branching Involved In Mammary Gland Duct Morphogenesis
Lens Fiber Cell Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Negative Regulation Of Lymphangiogenesis
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Bicellular Tight Junction Assembly
Pericyte Cell Differentiation
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Signaling
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Symbiont Entry Into Host Cell
Positive Regulation Of Receptor-mediated Endocytosis
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Ubiquitin-dependent Endocytosis
Cellular Response To Hypoxia
Regulation Of Intracellular Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by CSF1 (M-CSF) in myeloid cells
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Drugs
Dasatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Regorafenib
Fostamatinib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Alanine aminotransferase levels (
33339817
33547301
34315874
)
Aspartate aminotransferase levels (
33547301
34315874
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
27863252
29403010
22139419
32888494
33545615
)
Plateletcrit (
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Triglyceride levels (
33339817
)
Interacting Genes
81 interacting genes:
ABCB5
ACP1
AKT1
ANXA1
ARAF
ARNT
AURKA
BECN1
CBL
CBLC
CCND2
CD44
CDC42
CDH5
CDK17
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLDN4
DUSP14
DUSP18
DUSP19
DUSP26
DUSP29
EFNA1
EFNA2
EFNA3
EFNA4
EFNA5
EGFR
FZR1
GATAD1
GLIS2
GRB2
GRK2
GRM1
HGF
HIF1A
ILKAP
KDELR2
KPNA3
LATS2
LSM7
MAP2K5
MAP2K6
MAPK14
MDM4
MET
MSH2
MYC
NF1
NF2
NFIC
NUDT9
PIK3R1
PIK3R2
PPM1L
PSME2
PTEN
PTK2
PTPN11
PTPN7
PTPRR
RASA1
RASSF1
RBL1
RELA
RNF5
SHC1
SLA
STK11
STYX
TEAD2
TIAM1
TNFAIP1
TP53
TPTE
TPTE2
UBE4A
130 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PLK1
PRKCA
PRKCQ
PTEN
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
WWP1
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
Entrez ID
1969
867
HPRD ID
01494
01320
Ensembl ID
ENSG00000142627
ENSG00000110395
Uniprot IDs
P29317
P22681
PDB IDs
1MQB
2E8N
2K9Y
2KSO
2X10
2X11
3C8X
3CZU
3FL7
3HEI
3HPN
3KKA
3MBW
3MX0
3SKJ
4P2K
4PDO
4TRL
5EK7
5I9U
5I9V
5I9W
5I9X
5I9Y
5I9Z
5IA0
5IA1
5IA2
5IA3
5IA4
5IA5
5NJZ
5NK0
5NK1
5NK2
5NK3
5NK4
5NK5
5NK6
5NK7
5NK8
5NK9
5NKA
5NKB
5NKC
5NKD
5NKE
5NKF
5NKG
5NKH
5NKI
5NZ9
6B9L
6F7M
6F7N
6FNF
6FNG
6FNH
6HES
6HET
6HEU
6HEV
6HEW
6HEX
6HEY
6NJZ
6NK0
6NK1
6NK2
6NKP
6Q7B
6Q7C
6Q7D
6Q7E
6Q7F
6Q7G
6RW2
7B7N
7CZE
7CZF
7KJA
7KJB
7KJC
8BIN
8BIO
8BK0
8BM8
8BOC
8BOD
8BOF
8BOG
8BOH
8BOI
8BOK
8BOM
8QQY
8T9B
8TRS
8TRT
8TRV
8TV1
8TV5
8XPV
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
6XAR
7SIY
Enriched GO Terms of Interacting Partners
?
Regulation Of Intracellular Signal Transduction
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Cell Communication
Regulation Of Signaling
Protein Tyrosine Phosphatase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Cycle Process
Intracellular Signal Transduction
Phosphoprotein Phosphatase Activity
Negative Regulation Of Programmed Cell Death
Ephrin Receptor Binding
Phosphotyrosine Residue Binding
Negative Regulation Of Apoptotic Process
Cell Differentiation
Ephrin Receptor Signaling Pathway
Regulation Of Mitotic Cell Cycle
Regulation Of Programmed Cell Death
Regulation Of MAPK Cascade
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Adhesion
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Cellular Developmental Process
Response To Growth Factor
Protein Dephosphorylation
Negative Regulation Of Intracellular Signal Transduction
Protein Kinase Binding
Positive Regulation Of Signal Transduction
Animal Organ Development
MAPK Cascade
Developmental Process
Cellular Response To Stress
Positive Regulation Of Intracellular Signal Transduction
Response To Radiation
Response To UV
Regulation Of Protein Localization To Nucleus
Neurotrophin TRKA Receptor Binding
Negative Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune System Process
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Plasma Membrane
Activation Of Immune Response
Cell Activation
Leukocyte Activation
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Lymphocyte Activation
Non-membrane Spanning Protein Tyrosine Kinase Activity
ATP Binding
Fc Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Transferase Activity
Positive Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Cell Migration
Protein Phosphorylation
Phosphorylation
Nucleotide Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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