EPHA2 and EFNA5

Number of citations of the paper that reports this interaction (PMID 9245480)
2

Data Source:
HPRD (in vivo, in vitro)

		EPHA2	EFNA5
Gene Name		EPH receptor A2	ephrin-A5
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane	Extracellular Region Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding	Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Skeletal System Development Angiogenesis Vasculogenesis Osteoblast Differentiation Cell Adhesion Multicellular Organismal Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Viral Process Cell Migration Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Activation Of Rac GTPase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Apoptotic Process Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Rac GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs		Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)	Alzheimer's disease biomarkers ( 23419831) Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A	10 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 GRIP1 SRC
Entrez ID		1969	1946
HPRD ID		01494	03324
Ensembl ID		ENSG00000142627	ENSG00000184349
Uniprot IDs		P29317	P52803
PDB IDs		1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ	2X11 3MX0 4BK5 4BKA
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Locomotion Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Neuron Projection Development Cell Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis Neurotrophin Signaling Pathway Neuron Development Cell Morphogenesis Signal Transduction Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Signaling Regulation Of Signaling Cell Communication Fc Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Regulation Of ERBB Signaling Pathway Cell Motility Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Catalytic Activity Neurogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Regulation Of Body Fluid Levels	Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Neuron Projection Development Neuron Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Peptidyl-amino Acid Modification Neurogenesis Cell Morphogenesis Cell Development Locomotion Protein Phosphorylation Nervous System Development Movement Of Cell Or Subcellular Component Response To External Stimulus Phosphorylation Cell Differentiation Anatomical Structure Morphogenesis System Development Regulation Of Intracellular Signal Transduction Retinal Ganglion Cell Axon Guidance Phosphate-containing Compound Metabolic Process Regulation Of MAPK Cascade Axonal Fasciculation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cellular Protein Modification Process Fasciculation Of Motor Neuron Axon Anatomical Structure Development Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Cell Migration Fasciculation Of Sensory Neuron Axon Developmental Process Cell Motility Signaling
Tagcloud ?		abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip	adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive
Tagcloud (Difference) ?		abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip	adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive
Tagcloud (Intersection) ?