AKR7A2 and TRIM63

Number of citations of the paper that reports this interaction (PMID 15967462)
64

Data Source:
BioGRID (two hybrid)

		AKR7A2	TRIM63
Gene Name		aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	tripartite motif containing 63, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Golgi Apparatus Cytosol Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Electron Carrier Activity Phenanthrene-9,10-epoxide Hydrolase Activity	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Carbohydrate Metabolic Process Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Oxidation-reduction Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways		Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AKR7A3 F2 TRIM63	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		8574	84676
HPRD ID		04567	05843
Ensembl ID			ENSG00000158022
Uniprot IDs		O43488	B4DN95 Q969Q1
PDB IDs		2BP1	2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Skeletal Muscle Adaptation Negative Regulation Of Fibrinolysis Peptidyl-glutamic Acid Carboxylation Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Astrocyte Differentiation Fibrinolysis Regulation Of Platelet Activation Cellular Response To Dexamethasone Stimulus Positive Regulation Of Blood Coagulation Response To Dexamethasone Negative Regulation Of Glial Cell Differentiation Regulation Of Collagen Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Acute-phase Response Positive Regulation Of Coagulation Response To Electrical Stimulus Positive Regulation Of Wound Healing Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Glial Cell Differentiation Cellular Aldehyde Metabolic Process Regulation Of Calcium Ion Transport Into Cytosol Response To Interleukin-1 Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Calcium Ion Transport Proteolysis Regulation Of Blood Coagulation Regulation Of Gliogenesis	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?		aberrations aneuploid aneuploidy anxa2 belonged comparative differentially diploid endometrial endometrioid foremost genomic histopathological image imbalances ingenuity instability ipa mapped merit papillary ploidy profiling serous subgroups subjected upsc uterine validation	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		aberrations aneuploid aneuploidy anxa2 belonged comparative differentially diploid endometrial endometrioid foremost genomic histopathological image imbalances ingenuity instability ipa mapped merit papillary ploidy profiling serous subgroups subjected upsc uterine validation	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?