AKR7A2 and AKR7A3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AKR7A2	AKR7A3
Gene Name		aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Golgi Apparatus Cytosol Extracellular Vesicular Exosome	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Electron Carrier Activity Phenanthrene-9,10-epoxide Hydrolase Activity	Aldo-keto Reductase (NADP) Activity Electron Carrier Activity
	Biological Process	Carbohydrate Metabolic Process Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Oxidation-reduction Process	Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy	Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AKR7A3 F2 TRIM63	2 interactors: AKR7A2 TERF2IP
Entrez ID		8574	22977
HPRD ID		04567	07089
Ensembl ID
Uniprot IDs		O43488	O95154
PDB IDs		2BP1	2CLP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Skeletal Muscle Adaptation Negative Regulation Of Fibrinolysis Peptidyl-glutamic Acid Carboxylation Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Astrocyte Differentiation Fibrinolysis Regulation Of Platelet Activation Cellular Response To Dexamethasone Stimulus Positive Regulation Of Blood Coagulation Response To Dexamethasone Negative Regulation Of Glial Cell Differentiation Regulation Of Collagen Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Acute-phase Response Positive Regulation Of Coagulation Response To Electrical Stimulus Positive Regulation Of Wound Healing Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Glial Cell Differentiation Cellular Aldehyde Metabolic Process Regulation Of Calcium Ion Transport Into Cytosol Response To Interleukin-1 Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Calcium Ion Transport Proteolysis Regulation Of Blood Coagulation Regulation Of Gliogenesis	Negative Regulation Of DNA Recombination At Telomere Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Telomere Capping Daunorubicin Metabolic Process Doxorubicin Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Glycoside Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Quinone Metabolic Process Regulation Of DNA Repair Regulation Of DNA Recombination Cellular Aldehyde Metabolic Process Telomere Maintenance Cellular Ketone Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Response To DNA Damage Stimulus Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		aberrations aneuploid aneuploidy anxa2 belonged comparative differentially diploid endometrial endometrioid foremost genomic histopathological image imbalances ingenuity instability ipa mapped merit papillary ploidy profiling serous subgroups subjected upsc uterine validation	abcb4 anabolic bioassay built carcinogenic carcinogenicity carcinogens ccng1 cdkn1a dataset datasets employs formally gates generalizable informative integrates mathematical methodologies nongenotoxic omics phlda3 rankings reproducible rodent signatures subsamplings toxicogenomics virtue
Tagcloud (Difference) ?		aberrations aneuploid aneuploidy anxa2 belonged comparative differentially diploid endometrial endometrioid foremost genomic histopathological image imbalances ingenuity instability ipa mapped merit papillary ploidy profiling serous subgroups subjected upsc uterine validation	abcb4 anabolic bioassay built carcinogenic carcinogenicity carcinogens ccng1 cdkn1a dataset datasets employs formally gates generalizable informative integrates mathematical methodologies nongenotoxic omics phlda3 rankings reproducible rodent signatures subsamplings toxicogenomics virtue
Tagcloud (Intersection) ?