AKR7A2 and ZBTB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AKR7A2	ZBTB1
Description		aldo-keto reductase family 7 member A2	zinc finger and BTB domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nuclear Body Nuclear Membrane
	Molecular Function	Aldose Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Electron Transfer Activity Oxidoreductase Activity Phenanthrene-9,10-epoxide Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Carbohydrate Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity DNA Repair Chromatin Remodeling DNA Damage Response Translesion Synthesis Cell Differentiation B Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation T Cell Differentiation In Thymus Cellular Response To UV MRNA Transcription By RNA Polymerase II Innate Immune Response Positive Regulation Of T Cell Differentiation Thymus Development Protein Homooligomerization Positive Regulation Of Pro-T Cell Differentiation
Pathways		Aflatoxin activation and detoxification
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Lymphocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		5 interacting genes: AKR7A3 F2 MCPH1 TRIM63 ZBTB1	22 interacting genes: AKR7A2 AR EWSR1 FAM161A FANCG HEMGN KAT5 LZTR1 MAML3 MFAP1 NDN PCNA PIH1D2 PIM1 SCNM1 TRAF1 TRIM42 UBC UBE2I ZBTB25 ZNF417 ZNF572
Entrez ID		8574	22890
HPRD ID		04567	15688
Ensembl ID		ENSG00000053371	ENSG00000126804
Uniprot IDs		B4DZX4 O43488 V9HWA2	Q9Y2K1
PDB IDs		2BP1
Enriched GO Terms of Interacting Partners?			Nucleoplasm Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Zinc Ion Binding Regulation Of RNA Metabolic Process Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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