AKR7A2 and F2

Number of citations: 62 (PubMedID 9576847)
Data Source: HPRD (in vivo, in vitro)

		AKR7A2	F2
Name		aldo-keto reductase family 7 member A2	coagulation factor II, thrombin
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Aldose Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Electron Transfer Activity Oxidoreductase Activity Phenanthrene-9,10-epoxide Hydrolase Activity	Lipopolysaccharide Binding Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Thrombospondin Receptor Activity
	Biological Process	Carbohydrate Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process	Proteolysis Acute-phase Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Wounding Regulation Of Gene Expression Negative Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Negative Regulation Of Proteolysis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Astrocyte Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Cytolysis By Host Of Symbiont Cells Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Fibrinolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Thrombin-activated Receptor Signaling Pathway Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Aflatoxin activation and detoxification	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Platelet Aggregation (Plug Formation) Defective factor XII causes hereditary angioedema Defective F8 cleavage by thrombin Regulation of Complement cascade
Drugs		None	Lepirudin Bivalirudin Drotrecogin alfa Coagulation Factor IX (Recombinant) Menadione Argatroban Proflavine Enoxaparin Zinc 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide Beta-(2-Naphthyl)-Alanine Hemi-Babim 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine 4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-Amide 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 gamma-carboxy-L-glutamic acid 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Lysophosphotidylserine N-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINE TRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDE 2-[3-chloro-6-[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]imino-1-hydroxypyridin-2-yl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide 1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE 1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANE Suramin Ximelagatran Flovagatran Thrombomodulin Alfa Human C1-esterase inhibitor Dabigatran etexilate methyl L-phenylalaninate [(2R)-1-[(2S)-2-[[(2S,3S)-1-Chloro-6-(diaminomethylideneamino)-2-hydroxyhexan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]azanium (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE 6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID 6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE 1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamide D-leucyl-N-(3-chlorobenzyl)-L-prolinamide D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide 1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamide N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide 1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamide D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide (3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinoline D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide 2-[2-(4-Chloro-Phenylsulfanyl)-Acetylamino]-3-(4-Guanidino-Phenyl)-Propionamide 3-Carbamimidamido-1,1-diphenylurea N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide D-phenylalanyl-N-benzyl-L-prolinamide N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE 3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE GW-813893 N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE 4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL 2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) 1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE 4-TERT-BUTYLBENZENESULFONIC ACID 3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE 4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE 1-(2-{[(6-amino-2-methylpyridin-3-yl)methyl]amino}ethyl)-6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-ol (3Z,6S)-6-Chloro-1-(2-{[(5-chloro-1-benzothiophen-3-yl)methyl]amino}ethyl)-3-({2-[(2R)-2-piperidinyl]ethyl}imino)-2-piperazinol N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDE N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE 2-(6-Chloro-3-{[2,2-difluoro-2-(2-pyridinyl)ethyl]amino}-2-oxo-1(2H)-pyrazinyl)-N-[(2-fluoro-6-pyridinyl)methyl]acetamide 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE 3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTER AC-(D)Phe-pro-borolys-OH AC-(D)PHE-PRO-BOROHOMOLYS-OH AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamide 4-Hydroxyphenylpyruvic acid 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE (3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE 4-({[4-(3-METHYLBENZOYL)PYRIDIN-2-YL]AMINO}METHYL)BENZENECARBOXIMIDAMIDE 1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDE N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide 4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE 3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLE {(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate N-Methylphenylalanyl-N-[(trans-4-aminocyclohexyl)methyl]-L-prolinamide 2-Naphthalenesulfonic acid [PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINE 4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine Turoctocog alfa Copper Conestat alfa Kappadione Antithrombin Alfa Nafamostat Gabexate Anti-inhibitor coagulant complex Coagulation Factor IX Human Zinc acetate Turoctocog alfa pegol
Diseases		None	Inherited thrombophilia
GWAS		Blood protein levels ( 30072576 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Alzheimer's disease (late onset) ( 30820047 ) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Immunoglobulin A ( 20694011 ) Intraocular pressure ( 29617998 ) Lymphocyte count ( 32888494 ) Monocyte count ( 32888494 ) Prothrombin time ( 29403010 ) Schizophrenia ( 29483656 ) Thrombosis ( 26908601 ) Thumb osteoarthritis severity (hand Klsum) ( 33055079 ) Venous thromboembolism ( 25772935 28373160 31420334 31676865 )
Interacting Genes		5 interacting genes: AKR7A3 F2 MCPH1 TRIM63 ZBTB1	43 interacting genes: AANAT AKR7A2 AMBP C6 CAMP CPB2 DDIT3 F10 F11 F13A1 F2R F2RL1 F2RL2 F2RL3 F5 F8 F9 FGA GGCX GP1BA GP5 HGFAC IGFBP3 IGFBP5 ITGA2B KNG1 MAPT PLAU PROC PROS1 PROZ SERPINA5 SERPINB6 SERPINB8 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPING1 SPP1 ST13 THBD THBS1
Entrez ID		8574	2147
HPRD ID		04567	01488
Ensembl ID		ENSG00000053371	ENSG00000180210
Uniprot IDs		B4DZX4 O43488 V9HWA2	P00734
PDB IDs		2BP1	1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX 1BMM 1BMN 1BTH 1C1U 1C1V 1C1W 1C4U 1C4V 1C4Y 1C5L 1C5N 1C5O 1CA8 1D3D 1D3P 1D3Q 1D3T 1D4P 1D6W 1D9I 1DE7 1DIT 1DM4 1DOJ 1DWB 1DWC 1DWD 1DWE 1DX5 1E0F 1EB1 1EOJ 1EOL 1FPC 1FPH 1G30 1G32 1G37 1GHV 1GHW 1GHX 1GHY 1GJ4 1GJ5 1H8D 1H8I 1HAG 1HAH 1HAI 1HAO 1HAP 1HBT 1HDT 1HGT 1HLT 1HUT 1HXE 1HXF 1IHS 1IHT 1JMO 1JOU 1JWT 1K21 1K22 1KTS 1KTT 1LHC 1LHD 1LHE 1LHF 1LHG 1MH0 1MU6 1MU8 1MUE 1NM6 1NO9 1NRN 1NRO 1NRP 1NRQ 1NRR 1NRS 1NT1 1NU7 1NU9 1NY2 1NZQ 1O0D 1O2G 1O5G 1OOK 1OYT 1P8V 1PPB 1QBV 1QHR 1QJ1 1QJ6 1QJ7 1QUR 1RD3 1RIW 1SB1 1SFQ 1SG8 1SGI 1SHH 1SL3 1SR5 1T4U 1T4V 1TA2 1TA6 1TB6 1TBZ 1THP 1THR 1THS 1TMB 1TMT 1TMU 1TOM 1TQ0 1TQ7 1TWX 1UMA 1UVS 1VR1 1VZQ 1W7G 1WAY 1WBG 1XM1 1XMN 1YPE 1YPG 1YPJ 1YPK 1YPL 1YPM 1Z71 1Z8I 1Z8J 1ZGI 1ZGV 1ZRB 2A0Q 2A2X 2A45 2AFQ 2ANK 2ANM 2B5T 2BDY 2BVR 2BVS 2BVX 2BXT 2BXU 2C8W 2C8X 2C8Y 2C8Z 2C90 2C93 2CF8 2CF9 2CN0 2FEQ 2FES 2GDE 2GP9 2H9T 2HGT 2HNT 2HPP 2HPQ 2HWL 2JH0 2JH5 2JH6 2OD3 2PGB 2PGQ 2PKS 2PW8 2R2M 2THF 2UUF 2UUJ 2UUK 2V3H 2V3O 2ZC9 2ZDA 2ZDV 2ZF0 2ZFF 2ZFP 2ZFQ 2ZFR 2ZG0 2ZGB 2ZGX 2ZHE 2ZHF 2ZHQ 2ZHW 2ZI2 2ZIQ 2ZNK 2ZO3 3B23 3B9F 3BEF 3BEI 3BF6 3BIU 3BIV 3BV9 3C1K 3C27 3D49 3DA9 3DD2 3DHK 3DT0 3DUX 3E6P 3EE0 3EGK 3EQ0 3F68 3GIC 3GIS 3HAT 3HKJ 3HTC 3JZ1 3JZ2 3K65 3LDX 3LU9 3NXP 3P17 3P6Z 3P70 3PMH 3PO1 3QDZ 3QGN 3QLP 3QTO 3QTV 3QWC 3QX5 3R3G 3RLW 3RLY 3RM0 3RM2 3RML 3RMM 3RMN 3RMO 3S7H 3S7K 3SHA 3SHC 3SI3 3SI4 3SQE 3SQH 3SV2 3T5F 3TU7 3U69 3U8O 3U8R 3U8T 3U98 3U9A 3UTU 3UWJ 3VXE 3VXF 4AX9 4AYV 4AYY 4AZ2 4BAH 4BAK 4BAM 4BAN 4BAO 4BAQ 4BOH 4CH2 4CH8 4DIH 4DII 4DT7 4DY7 4E05 4E06 4E7R 4H6S 4H6T 4HFP 4HTC 4HZH 4I7Y 4LOY 4LXB 4LZ1 4LZ4 4MLF 4NZQ 4O03 4RKJ 4RKO 4RN6 4THN 4UD9 4UDW 4UE7 4UEH 4UFD 4UFE 4UFF 4UFG 4YES 5A2M 5AF9 5AFY 5AFZ 5AHG 5CMX 5DO4 5E8E 5EDK 5EDM 5EW1 5EW2 5GDS 5GIM 5JDU 5JFD 5JZY 5L6N 5MJT 5MLS 5MM6 5NHU 5TO3 5Z5W 5Z5X 6BJR 6C2W 6EO6 6EO7 6EO8 6EO9 6V5T 7KME 7TPP 8BWW 8KME 8RTN 8UF7 9CLN 9CLS 9CMO 9CTH
GO Terms Enriched among Interactors		None	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Response To Wounding Regulation Of Wound Healing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Extracellular Region Negative Regulation Of Wound Healing Regulation Of Biological Quality Endoplasmic Reticulum Lumen Fibrinolysis Protein Activation Cascade Platelet Alpha Granule Lumen Thrombin-activated Receptor Activity Peptidase Inhibitor Activity Protein Maturation Serine-type Endopeptidase Inhibitor Activity Extracellular Exosome Negative Regulation Of Multicellular Organismal Process Extracellular Matrix Thrombin-activated Receptor Signaling Pathway Zymogen Activation Regulation Of Fibrinolysis Blood Microparticle Platelet Alpha Granule Negative Regulation Of Plasminogen Activation Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Protease Binding Positive Regulation Of Coagulation Protein Metabolic Process Platelet Activation Negative Regulation Of Fibrinolysis Regulation Of Multicellular Organismal Process Regulation Of Plasminogen Activation Serine-type Endopeptidase Activity Heparin Binding Serine Protease Inhibitor Complex Golgi Lumen Negative Regulation Of Protein Processing Positive Regulation Of Interleukin-8 Production Regulation Of Protein Maturation Positive Regulation Of Wound Healing Serine-type Peptidase Activity