UBASH3B and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 17588522)
0

Data Source:
BioGRID (enzymatic study)

		UBASH3B	UBE2H
Description		ubiquitin associated and SH3 domain containing B	ubiquitin conjugating enzyme E2 H
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Signal Transduction Negative Regulation Of Signal Transduction Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 25961943 20686565 24097068) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Serum immune biomarker levels ( 32066700) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		84959	7328
HPRD ID		16463	03052
Ensembl ID		ENSG00000154127	ENSG00000186591
Uniprot IDs		Q8TF42	A0A3B3IU20 A4D1L5 P62256
PDB IDs		2CPW 2E5K 5VR6 5W5G 8U5M 8U7E	2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity Proteolysis Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Protein Autoubiquitination Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Transferase Activity Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Protein Monoubiquitination Receptor Tyrosine Kinase Binding Positive Regulation Of Metabolic Process Protein Binding Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination Phosphotyrosine Residue Binding Cytosol SH3 Domain Binding Regulation Of Primary Metabolic Process Regulation Protein Catabolic Process At Postsynapse Apoptotic Signaling Pathway Macromolecule Metabolic Process Organelle Localization P53 Binding Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Protein Polymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
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