UBASH3B and CBLB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		UBASH3B	CBLB
Description		ubiquitin associated and SH3 domain containing B	Cbl proto-oncogene B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Negative Regulation Of Signal Transduction Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation	Positive Regulation Of T Cell Anergy T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of Protein Catabolic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 25961943 20686565 24097068) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Serum immune biomarker levels ( 32066700) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840 28445677 31604244) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL	53 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 OSTF1 PIK3R1 PLCG2 PRMT2 PTK6 RET RNF11 SH3KBP1 SH3RF1 SHC1 SORBS2 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 VAV3 VPS26C YES1 ZAP70
Entrez ID		84959	868
HPRD ID		16463	05136
Ensembl ID		ENSG00000154127	ENSG00000114423
Uniprot IDs		Q8TF42	B3KSS7 B4DYP3 B7ZAG1 Q13191
PDB IDs		2CPW 2E5K 5VR6 5W5G 8U5M 8U7E	2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI 8GCY 8QNG 8QNH 8QNI 8QTG 8QTH 8QTJ 8QTK 8VW4 8VW5 9FQH 9FQI 9FQJ
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity Proteolysis Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Protein Autoubiquitination Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Transferase Activity Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Protein Monoubiquitination Receptor Tyrosine Kinase Binding Positive Regulation Of Metabolic Process Protein Binding Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination Phosphotyrosine Residue Binding Cytosol SH3 Domain Binding Regulation Of Primary Metabolic Process Regulation Protein Catabolic Process At Postsynapse Apoptotic Signaling Pathway Macromolecule Metabolic Process Organelle Localization P53 Binding Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Protein Polymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell Motility Positive Regulation Of Cell Communication Cytoplasm Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Intracellular Signaling Cassette Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Leukocyte Migration Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Lymphocyte Activation Lamellipodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lamellipodium Organization Regulation Of Cell Activation Fc-epsilon Receptor Signaling Pathway Leukocyte Activation Immune System Process Cytosol T Cell Activation Positive Regulation Of Cell Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?