UBASH3B and CBLB

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		UBASH3B	CBLB
Gene Name		ubiquitin associated and SH3 domain containing B	Cbl proto-oncogene B, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Phosphotyrosine Binding Ubiquitin-protein Transferase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Peptidyl-tyrosine Dephosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Platelet Aggregation	Positive Regulation Of T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Intracellular Signal Transduction T Cell Activation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) HDL cholesterol ( 20686565)	Multiple sclerosis ( 20453840)
Protein-Protein Interactions		21 interactors: CBL CBLB DAZAP2 DMRT3 DOC2A FAM168A JAK2 KHDRBS1 PARK2 RCHY1 SLC25A48 SPRY2 SYK UBB UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B	32 interactors: ARHGEF7 BLNK CRKL CRY1 EGFR FLT3 FYB FYN GLRX3 GORASP2 GRB2 HNRNPK KIT NCK1 NCK2 NEDD4 PIK3R1 PLCG2 RET RNF11 SH3KBP1 SHC1 SORBS3 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3B UBC VAV1 VAV2 ZAP70
Entrez ID		84959	868
HPRD ID		16463	05136
Ensembl ID		ENSG00000154127	ENSG00000114423
Uniprot IDs		Q8TF42	B3KSS7 Q13191
PDB IDs		2CPW 2E5K	2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Response To Hypoxia	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cell Migration Locomotion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lymphocyte Activation Immune Response Signal Transduction Cell Motility Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Leukocyte Migration Response To Growth Factor Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Leukocyte Activation Signaling Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Regulation Of Phosphorylation Regulation Of Immune System Process Single Organismal Cell-cell Adhesion Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Adhesion Regulation Of Phosphorus Metabolic Process Antigen Receptor-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Innate Immune Response Response To Organic Substance Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway
Tagcloud ?		adaptor blots cooh degranulation fcepsilonri gads gamma2 grb2 ige immunoblotting immunoprecipitations lysates mast nck nonphosphorylated phosphatases phospholipase phosphorylated precipitate precipitated precipitates representing shc ship slp sts syk tula tyrosines	calm3 ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		adaptor blots cooh degranulation fcepsilonri gads gamma2 grb2 ige immunoblotting immunoprecipitations lysates mast nck nonphosphorylated phosphatases phospholipase phosphorylated precipitate precipitated precipitates representing ship slp sts syk tula tyrosines	calm3 ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?		shc