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UBASH3B and UBE2C
Number of citations of the paper that reports this interaction (PubMedID
17588522
)
0
Data Source:
BioGRID
(enzymatic study)
UBASH3B
UBE2C
Description
ubiquitin associated and SH3 domain containing B
ubiquitin conjugating enzyme E2 C
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin-like Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Signal Transduction
Negative Regulation Of Signal Transduction
Platelet Activation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Collagen-activated Signaling Pathway
Regulation Of Osteoclast Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Bone Resorption
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Platelet Aggregation
Negative Regulation Of Platelet Aggregation
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Exit From Mitosis
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Blood urea nitrogen levels (
31152163
)
Cholesterol, total (
25961943
20686565
24097068
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
Eye length (
30174134
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
32203549
)
High density lipoprotein cholesterol levels (
33339817
)
High light scatter reticulocyte percentage of red cells (
32888494
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Pemphigus vulgaris (
29857070
)
Serum immune biomarker levels (
32066700
)
Stroke (
26089329
)
Systolic blood pressure (
30578418
)
Total cholesterol levels (
28334899
)
Height (
31562340
)
Interacting Genes
51 interacting genes:
BBC3
CBL
CBLB
CCDC74B
CUL3
DAZAP2
DISC1
DLGAP2
DMRT3
DOC2A
DTX3
EFS
FAM168A
HOXB2
INCA1
JAK2
KAT5
KDM1A
KHDRBS1
KPRP
LMO2
LZTS2
MAP3K1
PIAS2
PKP4
PRKN
PRR35
PSMB1
PTPN21
RCHY1
REL
RNF216
RNF41
SHC1
SLC25A48
SPRY2
SYK
TCF4
TEPSIN
TNKS
TP53BP2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
VPS37B
WASL
36 interacting genes:
ANAPC11
ANAPC2
AURKA
CDC20
CKAP2
CXCR1
DTX1
ENO2
HECTD3
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
RAG1
RBX1
RELA
RNF167
RNF31
RNF6
RNF7
RYR2
STUB1
TNNC1
TRIM13
TRIM2
TRIM21
TRIM28
TRIM29
UBA1
UBA6
UBASH3B
UBC
UBE3D
Entrez ID
84959
11065
HPRD ID
16463
05717
Ensembl ID
ENSG00000154127
ENSG00000175063
Uniprot IDs
Q8TF42
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
PDB IDs
2CPW
2E5K
5VR6
5W5G
8U5M
8U7E
1I7K
4YII
5A31
5KHR
5L9U
8TAR
8TAU
Enriched GO Terms of Interacting Partners
?
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Protein Modification Process
Macromolecule Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Ubiquitin Protein Ligase Activity
Proteolysis
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Protein Ubiquitination
Protein Autoubiquitination
Protein Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Transferase Activity
Catabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Monoubiquitination
Receptor Tyrosine Kinase Binding
Positive Regulation Of Metabolic Process
Protein Binding
Regulation Of Protein Metabolic Process
Protein K11-linked Ubiquitination
Phosphotyrosine Residue Binding
Cytosol
SH3 Domain Binding
Regulation Of Primary Metabolic Process
Regulation Protein Catabolic Process At Postsynapse
Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Organelle Localization
P53 Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Protein Polymerization
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cellular Component Organization
Cell Surface Receptor Signaling Pathway
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Ubiquitin Protein Ligase Activity
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein Modification Process
Catabolic Process
Protein Polyubiquitination
Protein Metabolic Process
Ubiquitin Protein Ligase Binding
Protein Autoubiquitination
Transferase Activity
Protein Monoubiquitination
Protein K48-linked Ubiquitination
Macromolecule Metabolic Process
Ubiquitin-ubiquitin Ligase Activity
Cullin Family Protein Binding
Protein K6-linked Ubiquitination
Protein K63-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Autophagy
Positive Regulation Of Catabolic Process
Protein K29-linked Ubiquitination
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Zinc Ion Binding
Cullin-RING Ubiquitin Ligase Complex
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Protein K27-linked Ubiquitination
Suppression Of Viral Release By Host
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Branched Polyubiquitination
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stress
Regulation Of Protein Catabolic Process
Anaphase-promoting Complex
Ubiquitin Activating Enzyme Activity
Ubiquitin-like Protein Ligase Activity
Anaphase-promoting Complex-dependent Catabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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