UBASH3B

Gene Name		ubiquitin associated and SH3 domain containing B
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Peptidyl-tyrosine Dephosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Platelet Aggregation
Pathways
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) HDL cholesterol ( 20686565)
Protein-protein Interactions		21 interactors: CBL CBLB DAZAP2 DMRT3 DOC2A FAM168A JAK2 KHDRBS1 PARK2 RCHY1 SLC25A48 SPRY2 SYK UBB UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B
Entrez ID		84959
HPRD ID		16463
Ensembl ID		ENSG00000154127
Uniprot IDs		Q8TF42
PDB IDs		2CPW 2E5K
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Response To Hypoxia
Tagcloud ?		adaptor blots cooh degranulation fcepsilonri gads gamma2 grb2 ige immunoblotting immunoprecipitations lysates mast nck nonphosphorylated phosphatases phospholipase phosphorylated precipitate precipitated precipitates representing shc ship slp sts syk tula tyrosines