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UBASH3B and UBE2D1
Number of citations of the paper that reports this interaction (PubMedID
17588522
)
0
Data Source:
BioGRID
(enzymatic study)
UBASH3B
UBE2D1
Description
ubiquitin associated and SH3 domain containing B
ubiquitin conjugating enzyme E2 D1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Signal Transduction
Negative Regulation Of Signal Transduction
Platelet Activation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Collagen-activated Signaling Pathway
Regulation Of Osteoclast Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Bone Resorption
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Platelet Aggregation
Negative Regulation Of Platelet Aggregation
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Polyubiquitination
Negative Regulation Of TORC1 Signaling
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Blood urea nitrogen levels (
31152163
)
Cholesterol, total (
25961943
20686565
24097068
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
Eye length (
30174134
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
32203549
)
High density lipoprotein cholesterol levels (
33339817
)
High light scatter reticulocyte percentage of red cells (
32888494
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Pemphigus vulgaris (
29857070
)
Serum immune biomarker levels (
32066700
)
Stroke (
26089329
)
Systolic blood pressure (
30578418
)
Total cholesterol levels (
28334899
)
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Interacting Genes
51 interacting genes:
BBC3
CBL
CBLB
CCDC74B
CUL3
DAZAP2
DISC1
DLGAP2
DMRT3
DOC2A
DTX3
EFS
FAM168A
HOXB2
INCA1
JAK2
KAT5
KDM1A
KHDRBS1
KPRP
LMO2
LZTS2
MAP3K1
PIAS2
PKP4
PRKN
PRR35
PSMB1
PTPN21
RCHY1
REL
RNF216
RNF41
SHC1
SLC25A48
SPRY2
SYK
TCF4
TEPSIN
TNKS
TP53BP2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
VPS37B
WASL
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARK2C
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
CUL4A
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL2
FBXL20
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HECTD1
HECW1
HERC2
HERC3
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KEAP1
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MIB2
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NQO1
NR1H2
OBI1
PELI1
PJA2
PMAIP1
POLL
POLM
POLR2E
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF207
RNF216
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SPOP
STAM2
STUB1
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM21
TRIM22
TRIM23
TRIM24
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM72
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBR5
UBTD1
UFM1
UHRF1
UHRF2
USP21
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
ZRANB1
Entrez ID
84959
7321
HPRD ID
16463
04267
Ensembl ID
ENSG00000154127
ENSG00000072401
Uniprot IDs
Q8TF42
A0A087WW00
P51668
PDB IDs
2CPW
2E5K
5VR6
5W5G
8U5M
8U7E
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
7ZJ3
Enriched GO Terms of Interacting Partners
?
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Protein Modification Process
Macromolecule Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Ubiquitin Protein Ligase Activity
Proteolysis
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Protein Ubiquitination
Protein Autoubiquitination
Protein Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Transferase Activity
Catabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Monoubiquitination
Receptor Tyrosine Kinase Binding
Positive Regulation Of Metabolic Process
Protein Binding
Regulation Of Protein Metabolic Process
Protein K11-linked Ubiquitination
Phosphotyrosine Residue Binding
Cytosol
SH3 Domain Binding
Regulation Of Primary Metabolic Process
Regulation Protein Catabolic Process At Postsynapse
Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Organelle Localization
P53 Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Protein Polymerization
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cellular Component Organization
Cell Surface Receptor Signaling Pathway
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Macromolecule Catabolic Process
Zinc Ion Binding
Macromolecule Metabolic Process
Proteolysis
Catabolic Process
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Metal Ion Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Cytoplasm
Protein Monoubiquitination
Response To Stress
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Post-translational Protein Modification
Cytosol
Immune System Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
DNA Damage Response
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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