USP5 and UBTD2

Number of citations of the paper that reports this interaction (PubMedID 25207809)
50

Data Source:
BioGRID (pull down, affinity chromatography technology)

		USP5	UBTD2
Description		ubiquitin specific peptidase 5	ubiquitin domain containing 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Presynapse	Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Binding Metal Ion Binding Deubiquitinase Activity	Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Proteolysis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Activation Protein K48-linked Deubiquitination Regulation Protein Catabolic Process At Presynapse Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		30 interacting genes: APP CD274 DAZAP2 DVL2 ISG15 METTL3 PDCD1 PJA1 PLA2G2A RFFL RNF11 RNF216 SGTA SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBE2S UBTD2 USP28 WWP2	14 interacting genes: AQP6 ARID5A GPS2 INCA1 KLHL35 MRPL17 MVP RNF4 TRIB3 TRIM39 UBA1 UBE2D4 USP5 YPEL3
Entrez ID		8078	92181
HPRD ID		03265	13118
Ensembl ID		ENSG00000111667	ENSG00000168246
Uniprot IDs		A0A140VJZ1 P45974	B3KMW8 Q8WUN7
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G 7MS5 7MS6 7MS7	1TTN 2KSN
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Innate Immune Response Protein Metabolic Process Protein Polyubiquitination Defense Response To Symbiont Immune Response Defense Response To Other Organism Response To External Biotic Stimulus Response To Other Organism Protein K63-linked Ubiquitination Transferase Activity Defense Response Suppression Of Viral Release By Host Immune System Process Collateral Sprouting In Absence Of Injury Host-mediated Suppression Of Symbiont Invasion Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Catabolic Process Response To Stress Proteolysis Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleus Positive Regulation Of T Cell Apoptotic Process Negative Regulation Of Immune Response To Tumor Cell Protein Tag Activity Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Nuclear Body Positive Regulation Of Lymphocyte Apoptotic Process	Nitrate Transmembrane Transporter Activity Negative Regulation Of Fat Cell Differentiation Transcription Corepressor Activity Cyclin Binding Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K6-linked Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Protein Kinase Inhibitor Activity Regulation Of Kinase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Negative Regulation Of Kinase Activity Negative Regulation Of Protein Kinase Activity Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Kinetochore Assembly Ubiquitin Activating Enzyme Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of T Cell Mediated Immunity Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Phosphorylation Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Negative Regulation Of Protein K63-linked Ubiquitination
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