USP5 and TRIML1

Number of citations of the paper that reports this interaction (PubMedID 19156909)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		USP5	TRIML1
Description		ubiquitin specific peptidase 5	tripartite motif family like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Presynapse	Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Binding Metal Ion Binding Deubiquitinase Activity	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Proteolysis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Activation Protein K48-linked Deubiquitination Regulation Protein Catabolic Process At Presynapse Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Ubiquitination Innate Immune Response
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Polycystic ovary syndrome ( 25574032) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		30 interacting genes: APP CD274 DAZAP2 DVL2 ISG15 METTL3 PDCD1 PJA1 PLA2G2A RFFL RNF11 RNF216 SGTA SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBE2S UBTD2 USP28 WWP2	4 interacting genes: APP MNAT1 RBCK1 USP5
Entrez ID		8078	339976
HPRD ID		03265	08774
Ensembl ID		ENSG00000111667	ENSG00000184108
Uniprot IDs		A0A140VJZ1 P45974	Q8N9V2
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G 7MS5 7MS6 7MS7
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Innate Immune Response Protein Metabolic Process Protein Polyubiquitination Defense Response To Symbiont Immune Response Defense Response To Other Organism Response To External Biotic Stimulus Response To Other Organism Protein K63-linked Ubiquitination Transferase Activity Defense Response Suppression Of Viral Release By Host Immune System Process Collateral Sprouting In Absence Of Injury Host-mediated Suppression Of Symbiont Invasion Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Catabolic Process Response To Stress Proteolysis Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleus Positive Regulation Of T Cell Apoptotic Process Negative Regulation Of Immune Response To Tumor Cell Protein Tag Activity Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Nuclear Body Positive Regulation Of Lymphocyte Apoptotic Process	Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Mitotic Cell Cycle Ubiquitin Binding Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Presynapse Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Immune Response Regulation Of DNA-templated Transcription Axon Midline Choice Point Recognition Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Cell Cycle CAK-ERCC2 Complex Transcription Factor TFIIK Complex Regulation Protein Catabolic Process At Presynapse LUBAC Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of RNA Metabolic Process
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