USP5 and TRIM26

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		USP5	TRIM26
Description		ubiquitin specific peptidase 5	tripartite motif containing 26
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Presynapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Binding Metal Ion Binding Deubiquitinase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Proteolysis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Activation Protein K48-linked Deubiquitination Regulation Protein Catabolic Process At Presynapse Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Immune System Process Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Protein K11-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Interferon gamma signaling
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 22883433 30285260 21926974) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		30 interacting genes: APP CD274 DAZAP2 DVL2 ISG15 METTL3 PDCD1 PJA1 PLA2G2A RFFL RNF11 RNF216 SGTA SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBE2S UBTD2 USP28 WWP2	32 interacting genes: BEND7 BIVM CEBPD CTNNB1 DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MECOM MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF126 SOX2 SUMO2 TAB1 THAP1 TLE5 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 USP5 ZEB1
Entrez ID		8078	7726
HPRD ID		03265	02901
Ensembl ID		ENSG00000111667	ENSG00000234127
Uniprot IDs		A0A140VJZ1 P45974	A0A024RCP3 Q12899
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G 7MS5 7MS6 7MS7
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Innate Immune Response Protein Metabolic Process Protein Polyubiquitination Defense Response To Symbiont Immune Response Defense Response To Other Organism Response To External Biotic Stimulus Response To Other Organism Protein K63-linked Ubiquitination Transferase Activity Defense Response Suppression Of Viral Release By Host Immune System Process Collateral Sprouting In Absence Of Injury Host-mediated Suppression Of Symbiont Invasion Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Catabolic Process Response To Stress Proteolysis Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleus Positive Regulation Of T Cell Apoptotic Process Negative Regulation Of Immune Response To Tumor Cell Protein Tag Activity Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Nuclear Body Positive Regulation Of Lymphocyte Apoptotic Process	Negative Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process CGAS/STING Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Epithelial Cell Differentiation Clathrin Vesicle Coat Regulation Of RNA Metabolic Process Protein Monoubiquitination Protein Polyubiquitination Regulation Of Epithelial Cell Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Ubiquitin Protein Ligase Activity Regulation Of Sister Chromatid Cohesion Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Type I Interferon Production Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of Cell Communication
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