TNNT3 and HAP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TNNT3	HAP1
Gene Name		troponin T type 3 (skeletal, fast)	huntingtin-associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon
	Molecular Function	Actin Binding Tropomyosin Binding Troponin C Binding Calcium-dependent ATPase Activity Troponin I Binding Calcium-dependent Protein Binding	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Striated Muscle Contraction Metabolic Process Muscle Filament Sliding Regulation Of ATPase Activity	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		6 interactors: HAP1 NUDT3 SNUPN TNNI2 TRIM63 TSG101	68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691
Entrez ID		7140	9001
HPRD ID		02822	02972
Ensembl ID		ENSG00000130595	ENSG00000173805
Uniprot IDs		P45378	P54257
PDB IDs
Enriched GO Terms of Interacting Partners?		Diphosphoinositol Polyphosphate Catabolic Process SnRNA Import Into Nucleus Positive Regulation Of Neurotrophin Production Diadenosine Polyphosphate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly Catabolic Process RNA Import Into Nucleus Regulation Of Exocytosis Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Cellular Macromolecule Catabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Muscle Contraction Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle System Process Muscle Atrophy Viral Budding Hypothalamus Cell Differentiation Skeletal Muscle Adaptation Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Retrograde Axon Cargo Transport Viral Protein Processing Regulation Of Vesicle-mediated Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Protein Transport Positive Regulation Of Synaptic Transmission, GABAergic Cellular Response To Organic Cyclic Compound Establishment Of Protein Localization Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation Intracellular Transport Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Aromatic Compound Catabolic Process Regulation Of Beta-amyloid Formation Virion Assembly Regulation Of Cilium Assembly Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Positive Regulation Of ERBB Signaling Pathway	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis
Tagcloud ?		11p15 2g7 biallelic biallelically bipaternal boundary clustered contiguous escape frames h19 homologue igf2 imprinted imprinting kb kip2 l23mrp lacks lies outline polyadenylated rodent spliced synteny troponin ubiquitously wilms wts	autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Difference) ?		11p15 2g7 biallelic biallelically bipaternal boundary clustered contiguous escape frames h19 homologue igf2 imprinted imprinting kb kip2 l23mrp lacks lies outline polyadenylated rodent spliced synteny troponin ubiquitously wilms wts	autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Intersection) ?