TNNT3 and CLIP4

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TNNT3	CLIP4
Description		troponin T3, fast skeletal type	CAP-Gly domain containing linker protein family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Nucleus Cell Cortex Microtubule Plus-end
	Molecular Function	Actin Binding Tropomyosin Binding Troponin C Binding Troponin I Binding Calcium-dependent Protein Binding	Protein Binding Microtubule Plus-end Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Striated Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of ATP-dependent Activity Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity	Cytoplasmic Microtubule Organization
Pathways		Striated Muscle Contraction
Drugs
Diseases		Distal arthrogryposis (DA)
GWAS		Appendicular lean mass ( 33097823) Celiac disease ( 23936387) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 30487518) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 27618448 30487518) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CLIP4 HAP1 NLGN3 NUDT3 SNUPN TNNI2 TRIM63 TSG101 TULP3 WASL	37 interacting genes: APP CDK5RAP2 CLIP1 CMYA5 DCAF6 DES DST DYNC2LI1 GLP1R HSF2BP JAKMIP2 KIF1B KIFC3 LZTS2 MAGEA12 MAP7 MAP7D1 MEOX2 MYBPC1 MYH3 PDE4DIP PEG10 RPS13 RPS27L RUNX1 SIX2 SON TACC3 TAF1 TNNT1 TNNT3 TPM1 TRIM32 TRIP13 TTN TULP3 ZNF114
Entrez ID		7140	79745
HPRD ID		02822	08634
Ensembl ID		ENSG00000130595	ENSG00000115295
Uniprot IDs		A0A286YFB1 A0A9L9PY19 H9KVA2 P45378	A0A8I5KXU9 A0A8I5QKP4 A0A8I5QKV0 A8K6D0 B7Z936 G3XAK3 Q8N3C7
PDB IDs			2Z0W
Enriched GO Terms of Interacting Partners?		Vesicle Localization Establishment Of Vesicle Localization Nucleus Positive Regulation Of Cellular Component Biogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Intraciliary Transport Particle A Binding Bronchus Morphogenesis Negative Regulation Of Membrane Tubulation Vesicle Cytoskeletal Trafficking Positive Regulation Of Clathrin-dependent Endocytosis Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Neurotrophin Production Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity SnRNA Import Into Nucleus 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Troponin T Binding Exosomal Secretion Organelle Localization Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Actin Cap RNA Import Into Nucleus Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Asymmetric, Glutamatergic, Excitatory Synapse Positive Regulation Of Cellular Component Organization Hypothalamus Cell Differentiation Skeletal Muscle Atrophy	Cytoskeleton Organization Sarcomere Organization Organelle Organization Microtubule-based Process Microtubule Cytoskeleton Organization Actomyosin Structure Organization Microtubule Skeletal Muscle Contraction Striated Muscle Contraction Microtubule Binding Muscle Filament Sliding Muscle Contraction Actin-myosin Filament Sliding Centrosome Actin Cytoskeleton Organization Cytoskeleton Microtubule Plus-end Microtubule Cytoskeleton Muscle System Process M Band Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Microtubule Polymerization Actin-mediated Cell Contraction Female Meiosis I Structural Constituent Of Muscle Troponin Complex Myofibril Male Meiotic Nuclear Division Regulation Of Supramolecular Fiber Organization Actin Filament-based Movement Contractile Muscle Fiber Tropomyosin Binding Regulation Of Microtubule Polymerization Cytoskeletal Protein Binding Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Meiotic Nuclear Division Female Meiotic Nuclear Division Axo-dendritic Transport Positive Regulation Of Cytoskeleton Organization Supramolecular Fiber Organization Retrograde Axonal Transport Microtubule Plus-end Binding Positive Regulation Of Protein Polymerization Cytoskeleton-dependent Intracellular Transport Myosin Filament Nuclear Division Regulation Of Cytoskeleton Organization Amyloid-beta Complex
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