TNNI2 and TNNC2

Number of citations: 31 (PubMedID 9560191)
Data Source: HPRD (in vitro)

		TNNI2	TNNC2
Name		troponin I2, fast skeletal type	troponin C2, fast skeletal type
Structure
GO Annotations	Cellular Component	Nucleus Cytosol Troponin Complex	Cytosol Troponin Complex
	Molecular Function	Actin Binding Protein Binding Troponin T Binding	Actin Binding Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Skeletal Muscle Contraction Positive Regulation Of DNA-templated Transcription Cardiac Muscle Contraction	Skeletal Muscle Contraction Regulation Of Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs		None	Felodipine Calcium Octylphenoxy polyethoxyethanol
Diseases		Distal arthrogryposis (DA)	None
GWAS		Celiac disease ( 23936387 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Inflammatory bowel disease ( 23128233 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: ACTB AIRIM CALM1 CTNNA3 DCAF11 DRC8 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2	4 interacting genes: PIK3R3 TBC1D1 TNNI2 TNNI3
Entrez ID		7136	7125
HPRD ID		01843	08929
Ensembl ID		ENSG00000130598	ENSG00000101470
Uniprot IDs		P48788	C9J7T9 P02585
PDB IDs		2MKP 7KAA	7KAA
GO Terms Enriched among Interactors		Troponin Complex Regulation Of Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Regulation Of System Process Nuclear Receptor Activity Striated Muscle Contraction Muscle Contraction Troponin I Binding Troponin T Binding Muscle System Process Transition Between Fast And Slow Fiber System Process Estrogen Response Element Binding Regulation Of Skeletal Muscle Adaptation Titin Binding Contractile Muscle Fiber Tropomyosin Binding Calcium-dependent Protein Binding Motile Cilium Intracellular Receptor Signaling Pathway Calyx Of Held Regulation Of Striated Muscle Contraction Nuclear Steroid Receptor Activity Axonemal A Tubule Inner Sheath Calcium Channel Complex Regulation Of Cardiac Muscle Cell Action Potential Steroid Binding Respiratory System Process Cilium Axonemal Microtubule Calcium Ion Binding Eye Photoreceptor Cell Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Photoreceptor Cell Development Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Regulation Of Muscle Filament Sliding Speed Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Substantia Nigra Development Actin Filament-based Process Cytosol Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Heart Contraction	Troponin T Binding Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiac Troponin Complex Troponin C Binding Muscle Contraction Muscle System Process 1-phosphatidylinositol-3-kinase Regulator Activity Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Myofibril Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Actin Binding Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Actin-myosin Filament Sliding Negative Regulation Of Anoikis Phosphatidylinositol-3-phosphate Biosynthetic Process Heart Contraction Cell Migration Involved In Sprouting Angiogenesis Regulation Of Anoikis Heart Process Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Blood Vessel Endothelial Cell Migration