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TNNI2 and ESRRA
Number of citations of the paper that reports this interaction (PMID
15604093
)
36
Data Source:
BioGRID
(two hybrid)
TNNI2
ESRRA
Gene Name
troponin I type 2 (skeletal, fast)
estrogen-related receptor alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Troponin Complex
Nucleus
Nucleoplasm
Nucleolus
Microtubule Cytoskeleton
Intercellular Bridge
Molecular Function
Actin Binding
Protein Binding
Troponin T Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Steroid Hormone Receptor Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
Biological Process
Skeletal Muscle Contraction
Regulation Of Muscle Contraction
Muscle Filament Sliding
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Organelle Organization
Mitochondrion Organization
Gene Expression
Intracellular Receptor Signaling Pathway
Regulation Of Cell Proliferation
Steroid Hormone Mediated Signaling Pathway
Regulation Of Osteoblast Differentiation
Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cartilage Development
Pathways
Striated Muscle Contraction
PPARA activates gene expression
Organelle biogenesis and maintenance
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activation of mitochondrial biogenesis
Mitochondrial biogenesis
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Crohn's disease (
21102463
)
Protein-Protein Interactions
13 interactors:
ACTB
CALM1
ESRRA
HNF4G
PKD2L1
RORB
TNNC1
TNNC2
TNNT1
TNNT3
TRIM55
TRIM63
UPF2
34 interactors:
ADH5
ATXN1
DPF1
DPF2
DPF3
DUT
EIF3I
ESR1
ESRRG
EXOSC6
FUS
GTF2B
HDAC8
KAT2B
LYST
MACF1
MAP2K5
NCOA1
NCOA3
NR0B1
NR0B2
NRIP1
NSD1
NXF1
PIAS4
PNRC2
PPARGC1A
PRKCD
PROX1
SIRT1
SMARCD3
SP1
SRC
TNNI2
Entrez ID
7136
2101
HPRD ID
01843
07210
Ensembl ID
ENSG00000130598
ENSG00000173153
Uniprot IDs
P48788
P11474
Q569H8
PDB IDs
1XB7
2PJL
3D24
3K6P
Enriched GO Terms of Interacting Partners
?
Muscle Contraction
Skeletal Muscle Contraction
Actin-myosin Filament Sliding
Muscle Filament Sliding
Muscle System Process
Musculoskeletal Movement
Actin-mediated Cell Contraction
Regulation Of Muscle Contraction
Actin Filament-based Movement
Striated Muscle Contraction
Cellular Response To Steroid Hormone Stimulus
Response To Steroid Hormone
Steroid Hormone Mediated Signaling Pathway
Cellular Response To Organic Cyclic Compound
Hormone-mediated Signaling Pathway
Response To Lipid
Cellular Response To Lipid
Response To Organic Cyclic Compound
Response To Hormone
Transcription Initiation From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Hormone Stimulus
Regulation Of ATPase Activity
DNA-templated Transcription, Initiation
Actin Filament-based Process
Neural Nucleus Development
Organ Development
Regulation Of Muscle Filament Sliding Speed
Movement Of Cell Or Subcellular Component
Regulation Of Striated Muscle Contraction
Midbrain Development
Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste
Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Muscle Filament Sliding
Diaphragm Contraction
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Regulation Of Osteoblast Differentiation
Cellular Response To Organic Substance
Signal Transduction
Amacrine Cell Differentiation
Regulation Of High Voltage-gated Calcium Channel Activity
Sensory Perception Of Sour Taste
Involuntary Skeletal Muscle Contraction
System Development
Skeletal Muscle Atrophy
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Response To Glucocorticoid
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Intracellular Receptor Signaling Pathway
Biosynthetic Process
Nitrogen Compound Metabolic Process
DNA-templated Transcription, Initiation
Intracellular Steroid Hormone Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Regulation Of Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Hormone Stimulus
Chromatin Modification
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Androgen Receptor Signaling Pathway
Reproductive Structure Development
Negative Regulation Of Cellular Metabolic Process
Reproductive System Development
Chromatin Organization
Response To Hormone
Tagcloud
?
biogenesis
constituent
coregulated
ctf1
dap3
elk1
elk4
exploring
gabpa
gtp
hdap3
homoeostasis
hox11
microarray
mitochondrial
nrf
oncocytic
pparg
presenting
publicly
ribosome
runx1
rxra
silico
tal1
ternary
tumourigenesis
tumours
upregulated
Tagcloud (Difference)
?
biogenesis
constituent
coregulated
ctf1
dap3
elk1
elk4
exploring
gabpa
gtp
hdap3
homoeostasis
hox11
microarray
mitochondrial
nrf
oncocytic
pparg
presenting
publicly
ribosome
runx1
rxra
silico
tal1
ternary
tumourigenesis
tumours
upregulated
Tagcloud (Intersection)
?