TNNI2 and TNNC1

Number of citations of the paper that reports this interaction (PMID 7103951)
10

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		TNNI2	TNNC1
Gene Name		troponin I type 2 (skeletal, fast)	troponin C type 1 (slow)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Troponin Complex	Nucleoplasm Mitochondrion Cytosol Troponin Complex Actin Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Troponin T Binding	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding Positive Regulation Of Transcription, DNA-templated	Diaphragm Contraction Regulation Of Muscle Contraction Response To Metal Ion Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs			Trifluoperazine Levosimendan Felodipine Bepridil Calcium Dihydroxyaluminium 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		13 interactors: ACTB CALM1 ESRRA HNF4G PKD2L1 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2	11 interactors: CDK1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBE2C
Entrez ID		7136	7134
HPRD ID		01843	08930
Ensembl ID		ENSG00000130598	ENSG00000114854
Uniprot IDs		P48788	P63316 Q6FH91
PDB IDs			1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG
Enriched GO Terms of Interacting Partners?		Muscle Contraction Skeletal Muscle Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Muscle System Process Musculoskeletal Movement Actin-mediated Cell Contraction Regulation Of Muscle Contraction Actin Filament-based Movement Striated Muscle Contraction Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Steroid Hormone Mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Hormone-mediated Signaling Pathway Response To Lipid Cellular Response To Lipid Response To Organic Cyclic Compound Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Hormone Stimulus Regulation Of ATPase Activity DNA-templated Transcription, Initiation Actin Filament-based Process Neural Nucleus Development Organ Development Regulation Of Muscle Filament Sliding Speed Movement Of Cell Or Subcellular Component Regulation Of Striated Muscle Contraction Midbrain Development Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Muscle Filament Sliding Diaphragm Contraction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Signal Transduction Amacrine Cell Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction System Development Skeletal Muscle Atrophy Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glucocorticoid	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of ATPase Activity Actin Filament-based Process Striated Muscle Contraction Striated Muscle Tissue Development Muscle Tissue Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Cardiac Chamber Development Muscle Structure Development Heart Development Skeletal Muscle Contraction Heart Morphogenesis Regulation Of ATPase Activity Musculoskeletal Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Muscle Organ Development Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Cardiovascular System Development Pronuclear Fusion Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of MRNA Processing Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination
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