TNNI2 and AIRIM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNNI2	AIRIM
Description		troponin I2, fast skeletal type	AFG2 interacting ribosome maturation factor
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GO Annotations	Cellular Component	Nucleus Cytosol Troponin Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Troponin T Binding	Protein Binding
	Biological Process	Skeletal Muscle Contraction Positive Regulation Of DNA-templated Transcription Cardiac Muscle Contraction	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		Striated Muscle Contraction
Drugs
Diseases		Distal arthrogryposis (DA)
GWAS		Celiac disease ( 23936387) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Inflammatory bowel disease ( 23128233) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		21 interacting genes: ACTB AIRIM CALM1 CTNNA3 DCAF11 DRC8 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2	144 interacting genes: ABI2 ADD1 ANTKMT ATP23 AVPI1 BORCS6 C1orf94 C1QTNF2 CBY2 CCDC120 CCDC125 CCDC33 CCDC88B CCHCR1 CDCA4 CEP55 CINP CRX CSNK2A1 CT55 CTAG1A CTAG1B DISC1 ECM1 ECSIT FAM217B FAM86C1P FTO GET4 GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 HESX1 HOOK2 HOXC8 IHO1 IKZF1 IKZF3 INKA1 KATNAL1 KIAA0753 KIFC3 KLF15 KRT13 KRT16 KRT18 KRT19 KRT24 KRT31 KRT35 KRT40 KRT75 KRT76 KRT80 KRTAP13-3 LDOC1 LMO2 LZTS2 MBD3L1 MDM4 MEI4 MEOX1 MEOX2 MIPOL1 MKRN2 MTFR1L MTUS2 NDUFB7 NECAB2 NFKBID NME4 NUP54 NUTM2F OOEP PAX5 PAX6 PAX7 PBX4 PDE4DIP PHC2 PLK4 PNMA1 POMC POU6F2 PPP1R12C PRDM6 PRMT5 PSMB4 PUDP REL RINT1 RNF20 RNF41 RPH3AL RUSC1 SAPCD2 SDCBP SERTAD1 SERTAD2 SLAIN1 SMARCD1 SOCS6 SORBS3 SPAG5 SPMIP6 STMN3 STN1 STX11 TADA2A TASOR2 TCF12 TCF4 TEKT4 TEPSIN TFIP11 TLE5 TNNI2 TRAF1 TRIM27 TRIM42 TRIM54 TSGA10IP TTC12 TTC23 TTC23L UHMK1 USH1G USHBP1 VBP1 VGLL1 VPS52 YPEL3 ZBED1 ZBTB42 ZMAT1 ZMAT5 ZMYND12 ZNF17 ZNF20 ZNF398 ZNF420 ZNF688 ZSCAN9
Entrez ID		7136	54955
HPRD ID		01843	07918
Ensembl ID		ENSG00000130598	ENSG00000116922
Uniprot IDs		P48788	B4DRQ5 B7Z9X8 Q9NX04
PDB IDs		2MKP 7KAA	8RHN
Enriched GO Terms of Interacting Partners?		Troponin Complex Regulation Of Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Regulation Of System Process Nuclear Receptor Activity Striated Muscle Contraction Muscle Contraction Troponin I Binding Troponin T Binding Muscle System Process Transition Between Fast And Slow Fiber System Process Estrogen Response Element Binding Regulation Of Skeletal Muscle Adaptation Titin Binding Contractile Muscle Fiber Tropomyosin Binding Calcium-dependent Protein Binding Motile Cilium Intracellular Receptor Signaling Pathway Calyx Of Held Regulation Of Striated Muscle Contraction Nuclear Steroid Receptor Activity Axonemal A Tubule Inner Sheath Calcium Channel Complex Regulation Of Cardiac Muscle Cell Action Potential Steroid Binding Respiratory System Process Cilium Axonemal Microtubule Calcium Ion Binding Eye Photoreceptor Cell Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Photoreceptor Cell Development Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Regulation Of Muscle Filament Sliding Speed Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Substantia Nigra Development Actin Filament-based Process Cytosol Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Heart Contraction	Cytoskeleton Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Organization Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Structural Molecule Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Centrosome Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Transcription Coactivator Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Microtubule Somite Specification
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