OTUB1 and TRIM54

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		OTUB1	TRIM54
Gene Name		OTU deubiquitinase, ubiquitin aldehyde binding 1	tripartite motif containing 54
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Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Signal Transducer Activity Microtubule Binding Zinc Ion Binding
	Biological Process	Immune System Process DNA Repair Proteolysis Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organismal Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ANXA1 ANXA7 BIRC2 CDKN1A ECT2 ESR1 H2AFX KDM1A PJA1 RFFL RHOA RNF126 RNF128 SMAD2 SMAD3 SMAD4 SMAD9 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S UBE2V2 USP15 USP21 USP28	127 interactors: ADCY4 ALS2CR11 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC67 CCDC87 CDK18 CDKN1A CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM STRA13 TBC1D22B TCEA2 TCEB3 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D3 UBE2I UBE2U UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 WDYHV1 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587
Entrez ID		55611	57159
HPRD ID		08493	05928
Ensembl ID			ENSG00000138100
Uniprot IDs		B3KUV5 Q96FW1	Q9BYV2
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	3Q1D
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Abiotic Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Response To Transforming Growth Factor Beta Cellular Protein Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K63-linked Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Response To Stress Protein Metabolic Process BMP Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Response To Hypoxia SMAD Protein Complex Assembly Regulation Of Cellular Process Cellular Metabolic Process Regulation Of Cell Proliferation Cellular Response To Stimulus Proteolysis Regulation Of Cell Death Negative Regulation Of Cell Death Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Response To Stimulus	Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Proteolysis Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Organelle Organization Regulation Of Protein Catabolic Process Protein Metabolic Process Histone Deubiquitination RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Process Monoubiquitinated Protein Deubiquitination Histone Modification Gene Expression RNA Biosynthetic Process Chromatin Modification Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Chromatin Organization Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Chromosome Organization Cellular Response To Heat Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic
Tagcloud (Difference) ?		2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic
Tagcloud (Intersection) ?