OTUB1 and TRIM63

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		OTUB1	TRIM63
Gene Name		OTU deubiquitinase, ubiquitin aldehyde binding 1	tripartite motif containing 63, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Immune System Process DNA Repair Proteolysis Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ANXA1 ANXA7 BIRC2 CDKN1A ECT2 ESR1 H2AFX KDM1A PJA1 RFFL RHOA RNF126 RNF128 SMAD2 SMAD3 SMAD4 SMAD9 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S UBE2V2 USP15 USP21 USP28	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		55611	84676
HPRD ID		08493	05843
Ensembl ID			ENSG00000158022
Uniprot IDs		B3KUV5 Q96FW1	B4DN95 Q969Q1
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Abiotic Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Response To Transforming Growth Factor Beta Cellular Protein Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K63-linked Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Response To Stress Protein Metabolic Process BMP Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Response To Hypoxia SMAD Protein Complex Assembly Regulation Of Cellular Process Cellular Metabolic Process Regulation Of Cell Proliferation Cellular Response To Stimulus Proteolysis Regulation Of Cell Death Negative Regulation Of Cell Death Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Response To Stimulus	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?		2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?