OTUB1 and PJA1

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		OTUB1	PJA1
Gene Name		OTU deubiquitinase, ubiquitin aldehyde binding 1	praja ring finger 1, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Immune System Process DNA Repair Proteolysis Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Protein Ubiquitination Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ANXA1 ANXA7 BIRC2 CDKN1A ECT2 ESR1 H2AFX KDM1A PJA1 RFFL RHOA RNF126 RNF128 SMAD2 SMAD3 SMAD4 SMAD9 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S UBE2V2 USP15 USP21 USP28	36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440
Entrez ID		55611	64219
HPRD ID		08493	02335
Ensembl ID			ENSG00000181191
Uniprot IDs		B3KUV5 Q96FW1	Q8NG27
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	2L0B
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Abiotic Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Response To Transforming Growth Factor Beta Cellular Protein Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K63-linked Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Response To Stress Protein Metabolic Process BMP Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Response To Hypoxia SMAD Protein Complex Assembly Regulation Of Cellular Process Cellular Metabolic Process Regulation Of Cell Proliferation Cellular Response To Stimulus Proteolysis Regulation Of Cell Death Negative Regulation Of Cell Death Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Response To Stimulus	Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic
Tagcloud (Difference) ?		2beta accord accordance adenosyl aggressiveness alls calponine classify collections cube daemon dataanalysis deubiquitinating drawing equipped favored i4 lc1200 lists lymphoblastes lymphoblastic lymphoblasts mascot msf myeloblastic ribonucleo septin spots tryptic
Tagcloud (Intersection) ?