OTUB1 and UBE2D4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		OTUB1	UBE2D4
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	ubiquitin conjugating enzyme E2 D4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Nucleus
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Inhibitor Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Adaptive Immune Response Immune System Process DNA Repair Proteolysis DNA Damage Response Protein Deubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Double-strand Break Repair	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)
Interacting Genes		59 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CCN6 CD274 CDKN1A CEBPA CPEB2 CSNK2A1 ECT2 ESR1 H2AX HSF1 IL1RL2 KDM1A LINC00857 MAPT MSH2 MYC NEDD8 OTUD6B PJA1 RFFL RHOA RNF126 RNF128 SETD7 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2S UBE2Z UBE4B USP15 USP21 USP28 YAP1	111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		55611	51619
HPRD ID		08493	14242
Ensembl ID		ENSG00000167770	ENSG00000078967
Uniprot IDs		B3KUV5 Q96FW1	Q9Y2X8
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Regulation Of Programmed Cell Death Protein Ubiquitination Regulation Of Apoptotic Process Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SMAD Binding Modification-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process In Utero Embryonic Development Negative Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Chordate Embryonic Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Proteolysis Involved In Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Stress Protein Polyubiquitination Proteolysis Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Gene Expression Regulation Of Developmental Process Ubiquitin Conjugating Enzyme Activity Response To Ionizing Radiation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Macromolecule Biosynthetic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion
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