OTUB1 and RNF128

Number of citations of the paper that reports this interaction (PubMedID 14661020)
0

Data Source:
BioGRID (pull down)

		OTUB1	RNF128
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	ring finger protein 128
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Inhibitor Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immune System Process DNA Repair Proteolysis DNA Damage Response Protein Deubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Double-strand Break Repair	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Lysosome Positive Regulation Of Protein Catabolic Process In The Vacuole
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Alcoholic chronic pancreatitis ( 28754779) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		59 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CCN6 CD274 CDKN1A CEBPA CPEB2 CSNK2A1 ECT2 ESR1 H2AX HSF1 IL1RL2 KDM1A LINC00857 MAPT MSH2 MYC NEDD8 OTUD6B PJA1 RFFL RHOA RNF126 RNF128 SETD7 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2S UBE2Z UBE4B USP15 USP21 USP28 YAP1	18 interacting genes: APPBP2 CD151 CD40LG CD81 CEP76 EGFR EPOR OTUB1 PDCD1 SNX17 TBK1 TP53 UBE2E1 UBE2H UBE2I UBE2N UBE2T UBQLN2
Entrez ID		55611	79589
HPRD ID		08493	02340
Ensembl ID		ENSG00000167770	ENSG00000133135
Uniprot IDs		B3KUV5 Q96FW1	Q8TEB7
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	3ICU
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Regulation Of Programmed Cell Death Protein Ubiquitination Regulation Of Apoptotic Process Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SMAD Binding Modification-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process In Utero Embryonic Development Negative Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Chordate Embryonic Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Proteolysis Involved In Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Stress Protein Polyubiquitination Proteolysis Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Gene Expression Regulation Of Developmental Process Ubiquitin Conjugating Enzyme Activity Response To Ionizing Radiation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Macromolecule Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Mononuclear Cell Proliferation Proteasomal Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Leukocyte Proliferation Ubiquitin Protein Ligase Binding Proteolysis Post-translational Protein Modification Protein Monoubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein Modification By Small Protein Conjugation Positive Regulation Of Canonical NF-kappaB Signal Transduction TOR Signaling Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Protein Modification Process Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of Cellular Response To Stress Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Communication Lymphocyte Proliferation Positive Regulation Of Signaling Protein Metabolic Process Lymphocyte Activation Involved In Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Immune System Process ATP Binding Protein Ubiquitination T Cell Apoptotic Process Cytosol Positive Regulation Of Leukocyte Apoptotic Process Integrin Binding Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Leukocyte Activation Involved In Immune Response Cellular Localization Cell Activation Involved In Immune Response
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