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PRKN and UBE2N
Number of citations of the paper that reports this interaction (PubMedID
25403879
)
78
Data Source:
BioGRID
(pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down)
PRKN
UBE2N
Description
parkin RBR E3 ubiquitin protein ligase
ubiquitin conjugating enzyme E2 N
Image
GO Annotations
Cellular Component
Golgi Membrane
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Synaptic Vesicle
Postsynaptic Density
Membrane
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Axon
Synaptic Vesicle Membrane
Protein-containing Complex
Cell Projection
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Synapse
Perinuclear Region Of Cytoplasm
Lewy Body
Intracellular Vesicle
Dopaminergic Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Conjugating Enzyme Complex
UBC13-MMS2 Complex
Protein-containing Complex
Extracellular Exosome
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Nucleotide Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Synaptic Transmission, Dopaminergic
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Autophagy
Response To Oxidative Stress
Response To Unfolded Protein
Mitochondrion Organization
Central Nervous System Development
Learning
Locomotory Behavior
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Positive Regulation Of Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Response To Muscle Activity
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Anatomical Structure Morphogenesis
Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Oxidative Stress
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Protein K27-linked Ubiquitination
Host-mediated Suppression Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Regulation Of Neurotransmitter Secretion
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Response To Corticosterone
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Mitochondrion Localization
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Necroptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Type 2 Mitophagy
Regulation Of Biological Quality
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Negative Regulation Of Excitatory Postsynaptic Potential
Cellular Response To Toxic Substance
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Mitochondrion To Lysosome Vesicle-mediated Transport
Regulation Protein Catabolic Process At Presynapse
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Mitophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Secretion By Cell
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Response To Curcumin
Cellular Response To L-glutamine
Cellular Response To Hydrogen Sulfide
Positive Regulation Of Type 2 Mitophagy
Cellular Response To L-glutamate
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein K63-linked Ubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Double-strand Break Repair
Pathways
PINK1-PRKN Mediated Mitophagy
Regulation of necroptotic cell death
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PINK1-PRKN Mediated Mitophagy
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Triglyceride levels in HIV infection (
33109212
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
131 interacting genes:
ADRM1
AIMP2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCND1
CDKN1A
CHPF
COMMD1
COXFA4L2
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EIF4B
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GATA4
GCK
GPR37
GRIN2B
GTPBP4
HDAC6
HEXD
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
MTOR
NEDD8
NEK2
NKRF
NQO1
PA2G4
PAFAH1B2
PDCD2
PHB2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RFFL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
SRSF1
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
VDR
YWHAH
ZNF622
ZNF746
124 interacting genes:
AMFR
ARIH1
ARIH2
ARK2C
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DTX3
DZIP3
F12
H2AC4
HERC2
HSP90AA1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RBX1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF167
RNF168
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TREX2
TRIM13
TRIM14
TRIM15
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM34
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM65
TRIM69
TRIM7
TRIM72
UBA1
UBB
UBE2V1
UBE2V2
UBE3A
UBE3B
UHRF1
XIAP
ZNRF2
ZNRF3
ZNRF4
Entrez ID
5071
7334
HPRD ID
03967
04725
Ensembl ID
ENSG00000185345
ENSG00000177889
Uniprot IDs
O60260
X5DR79
P61088
V9HW41
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
8IK6
8IKV
8JWV
8WZN
8WZO
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6LP2
6P5B
6S53
6ULH
6UMP
6UMS
7BBD
7BBF
7BXG
9BIV
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Macromolecule Catabolic Process
Cytosol
Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Proteolysis
Nucleus
Protein K48-linked Ubiquitination
Catabolic Process
Protein Modification Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Ubiquitin-like Protein Transferase Activity
Regulation Of Metabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Nucleoplasm
Mitochondrial Outer Membrane
Regulation Of Protein Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Proteolysis
Cytoplasm
Ubiquitin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
ATP Binding
Regulation Of Post-translational Protein Modification
Regulation Of Mitophagy
Transferase Activity
Protein Binding
Regulation Of Autophagy Of Mitochondrion
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Polyubiquitination
Zinc Ion Binding
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Macromolecule Catabolic Process
Metal Ion Binding
Protein K63-linked Ubiquitination
Protein Autoubiquitination
Proteolysis
Catabolic Process
Protein K48-linked Ubiquitination
Response To Stress
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stress
Regulation Of Intracellular Signal Transduction
Innate Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Protein Monoubiquitination
Immune System Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Defense Response To Symbiont
Cytoplasm
Defense Response To Other Organism
Positive Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Response To Other Organism
Ubiquitin Conjugating Enzyme Binding
Positive Regulation Of Metabolic Process
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