PRKN and PLK1

Number of citations of the paper that reports this interaction (PubMedID 35509820)
55

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PRKN	PLK1
Description		parkin RBR E3 ubiquitin protein ligase	polo like kinase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Postsynaptic Density Membrane Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Axon Synaptic Vesicle Membrane Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Lewy Body Intracellular Vesicle Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Chromatin Synaptonemal Complex Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Spindle Microtubule Microtubule Cytoskeleton Midbody Centriolar Satellite Spindle Midzone Mitotic Spindle Pole
	Molecular Function	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding Transferase Activity SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Synaptic Transmission, Dopaminergic Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Autophagy Response To Oxidative Stress Response To Unfolded Protein Mitochondrion Organization Central Nervous System Development Learning Locomotory Behavior Adult Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Response To Muscle Activity Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Anatomical Structure Morphogenesis Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Oxidative Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein K27-linked Ubiquitination Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Protein Stabilization Response To Corticosterone Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Localization Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Necroptotic Process Regulation Of Canonical Wnt Signaling Pathway Type 2 Mitophagy Regulation Of Biological Quality Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Negative Regulation Of Excitatory Postsynaptic Potential Cellular Response To Toxic Substance Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Protein Catabolic Process At Presynapse Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Secretion By Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Cellular Response To L-glutamine Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Cellular Response To L-glutamate Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Microtubule Bundle Formation Double-strand Break Repair Protein Phosphorylation Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Chromosome Condensation Mitotic Nuclear Membrane Disassembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Female Meiosis Chromosome Segregation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Protein Localization To Organelle Negative Regulation Of Apoptotic Process Homologous Chromosome Segregation Establishment Of Protein Localization Positive Regulation Of Proteolysis Golgi Inheritance Nuclear Membrane Disassembly Centrosome Separation Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Synaptonemal Complex Disassembly Protein Localization To Chromatin Protein Localization To Centrosome Protein Localization To Nuclear Envelope Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Localization To Cell Cortex Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase Mitotic Metaphase/Anaphase Transition Mitotic Telophase/Cytokinesis Cyclin A/B1/B2 associated events during G2/M transition The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea Wortmannin Fostamatinib Volasertib
Diseases		Parkinson's disease (PD)
GWAS		Triglyceride levels in HIV infection ( 33109212)	Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		131 interacting genes: ADRM1 AIMP2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCND1 CDKN1A CHPF COMMD1 COXFA4L2 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EIF4B EPS15 FAF1 FAM120A FBP1 FBXO7 FBXW7 GATA4 GCK GPR37 GRIN2B GTPBP4 HDAC6 HEXD IKBKG LSG1 MDM2 MEOX1 MEOX2 MFN1 MFN2 MRPL13 MRPL19 MRPL45 MTOR NEDD8 NEK2 NKRF NQO1 PA2G4 PAFAH1B2 PDCD2 PHB2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RALY RANBP2 RBCK1 REL RFFL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SF3B2 SF3B3 SIM2 SNCA SNCAIP SRSF1 STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z USP30 USP33 VDAC1 VDR YWHAH ZNF622 ZNF746	147 interacting genes: - ACTL6B AKAP12 APP ASPM BAG6 BCL2L1 BIRC6 BRCA2 BUB1 C6orf136 CBL CCNB1 CDC14A CDC25C CDC6 CEBPA CENPQ CENPU CEP55 CHEK2 CSN1S1 CSN2 CTNNB1 CUL4B DNAJB9 DNHD1 ECT2 EIF6 ERCC6L EYA1 EYA4 FBXL5 FBXW7 GET4 GLB1 GORASP1 HNRNPU IDH1 IDH2 IKBKB INTS11 ITSN1 KIF23 KIF2C KLF4 KLHL22 KRABD3 LMO4 LRP5L LRRK1 LRRK2 MAD2L1BP MAGED1 MCM2 MCM3 MCM7 MDM2 MISP MPP2 MYC MYT1 NCAPD3 NCAPG2 NCAPH2 NEDD1 NEDD4 NHSL2 NINL NPM1 NUDC PARP10 PHC2 PIN1 PITPNM1 PKMYT1 PON1 PPID PPIL2 PPP1R12A PPP6R2 PRC1 PRKN PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSRC1 PTEN PTPRD RAB1A RABAC1 RACGAP1 RAD51 RAP1GAP RECQL5 RELA REST RGCC RICTOR RNF126 RNF2 RSF1 RXRA SEPTIN9 SHCBP1 SIMC1 SNCA SNCB SPOUT1 SREBF1 STAG2 STUB1 SUGT1 TIMELESS TNFSF11 TOP2A TP53 TP53BP2 TP73 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 UBE2I UHRF1 USP16 USP7 VIM VMA22 VRK2 VRK3 WAC WEE1 ZNF71
Entrez ID		5071	5347
HPRD ID		03967	03652
Ensembl ID		ENSG00000185345	ENSG00000166851
Uniprot IDs		O60260 X5DR79	P53350
PDB IDs		1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13 8IK6 8IKV 8JWV 8WZN 8WZO	1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53 4LKL 4LKM 4O56 4O6W 4O9W 4RCP 4WHH 4WHK 4WHL 4X9R 4X9V 4X9W 5J19 5NEI 5NFU 5NJE 5NMM 5NN1 5NN2 5TA6 5TA8 6AX4 6GY2 7MSO 7MX1 8BJT 8CRC 8JOQ 8JOY 8S30 8S31 8WFP 8X72 8XB9
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Macromolecule Catabolic Process Cytosol Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Nucleus Protein K48-linked Ubiquitination Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Nucleotide Binding Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Regulation Of Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Nucleoplasm Mitochondrial Outer Membrane Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Proteolysis Cytoplasm Ubiquitin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Mitophagy Transferase Activity Protein Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process	Proteasome Core Complex Cell Division Cytoplasm Regulation Of Cell Cycle Nucleoplasm Regulation Of Cell Cycle Process Nucleus Cytosol Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteasome Complex Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Macromolecule Catabolic Process Positive Regulation Of Cell Cycle Proteasome Core Complex, Beta-subunit Complex Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Spindle Regulation Of Cell Cycle Phase Transition Proteasome Core Complex, Alpha-subunit Complex Regulation Of Cellular Response To Stress Microtubule-based Process Organelle Organization Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Midbody Proteolysis Regulation Of Intracellular Signal Transduction Cellular Response To Radiation DNA Repair Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Cytokinesis Macromolecule Metabolic Process Response To Xenobiotic Stimulus Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Segregation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Protein Kinase Binding Chromosome Regulation Of Chromosome Segregation
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