PARK2 and ATXN3

Number of citations of the paper that reports this interaction (PMID 22081612)
13

Data Source:
BioGRID (pull down, affinity chromatography technology, x-ray crystallography)

		PARK2	ATXN3
Gene Name		parkin RBR E3 ubiquitin protein ligase	ataxin 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm LUBAC Complex Lewy Body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body
	Molecular Function	G-protein Coupled Receptor Binding Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity SH3 Domain Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding	Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Protein Polyubiquitination Mitochondrial Fission Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Startle Response Transcription, DNA-templated Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Regulation Of Autophagy Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Regulation Of Dopamine Secretion Protein Ubiquitination Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Norepinephrine Metabolic Process Dopamine Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Protein K27-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Zinc Ion Homeostasis Negative Regulation Of Cell Death Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Aging ( 22773346) Disc degeneration (lumbar) ( 22993228) Metabolite levels ( 19043545) Pancreatic cancer ( 20686608)	Height ( 18391950 18391951) Orofacial clefts ( 22419666)
Protein-Protein Interactions		77 interactors: AIMP2 ARR3 ARRB2 ATXN3 BAG5 CASK CASP1 CASP8 CDK5 CHPF CRX CSNK1A1 CUL1 DLG1 DLX2 DNM1L DYT10 EPS15 FAM46C FBP1 FBXO7 FBXW7 GPR37 GRIN2B HEXDC IKBKG MEOX1 MEOX2 MFN1 NDUFA4L2 PAFAH1B2 PDCD2 PICK1 PRKACA PSMA1 PSMA7 PSMC5 PSMD4 RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 SEPT4 SEPT5 SIM2 SNCA SNCAIP STUB1 SYT11 TCF4 TOMM40 TOMM70A TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2J1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2V1 UCHL1 YWHAH ZNF746	43 interactors: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CASP1 CDKN1A CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MKNK1 NCOR1 PARK2 PICK1 PJA1 PSMD7 RAD23A RAD23B RFFL RPS6KA1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP
Entrez ID		5071	4287
HPRD ID		03967	06131
Ensembl ID		ENSG00000185345	ENSG00000066427
Uniprot IDs		O60260 Q5VVX4	P54252
PDB IDs		1IYF 2JMO 4BM9 4I1F 4I1H	1YZB 2AGA 2DOS 2JRI 2KLZ
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Death Death Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Catalytic Activity Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cell Death Catabolic Process Response To Growth Factor Protein Metabolic Process Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process
Tagcloud ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor	14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Difference) ?		ataxin atp13a2 b12 cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic kufor levodopa lyst parkin parkinsonism pn polg1 premutation rakeb tremor	14q32 amplifies ataxia atm atnx3 break breaks deposited eventually expansions glutamine inactivated inefficient mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Intersection) ?		atxn3 cag joseph machado