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PRKN and TUBB
Number of citations of the paper that reports this interaction (PubMedID
12716939
)
35
Data Source:
HPRD
(in vivo)
PRKN
TUBB
Description
parkin RBR E3 ubiquitin protein ligase
tubulin beta class I
Image
GO Annotations
Cellular Component
Golgi Membrane
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Synaptic Vesicle
Postsynaptic Density
Membrane
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Axon
Synaptic Vesicle Membrane
Protein-containing Complex
Cell Projection
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Synapse
Perinuclear Region Of Cytoplasm
Lewy Body
Intracellular Vesicle
Dopaminergic Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Extracellular Region
Nucleus
Nuclear Envelope Lumen
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Microtubule Cytoskeleton
Protein-containing Complex
Azurophil Granule Lumen
Cytoplasmic Ribonucleoprotein Granule
Cell Body
Membrane Raft
Intercellular Bridge
Extracellular Exosome
Mitotic Spindle
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Nucleotide Binding
GTPase Activity
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
GTPase Activating Protein Binding
MHC Class I Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Synaptic Transmission, Dopaminergic
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Autophagy
Response To Oxidative Stress
Response To Unfolded Protein
Mitochondrion Organization
Central Nervous System Development
Learning
Locomotory Behavior
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Positive Regulation Of Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Response To Muscle Activity
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Anatomical Structure Morphogenesis
Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Oxidative Stress
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Protein K27-linked Ubiquitination
Host-mediated Suppression Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Regulation Of Neurotransmitter Secretion
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Response To Corticosterone
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Mitochondrion Localization
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Necroptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Type 2 Mitophagy
Regulation Of Biological Quality
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Negative Regulation Of Excitatory Postsynaptic Potential
Cellular Response To Toxic Substance
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Mitochondrion To Lysosome Vesicle-mediated Transport
Regulation Protein Catabolic Process At Presynapse
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Mitophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Secretion By Cell
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Response To Curcumin
Cellular Response To L-glutamine
Cellular Response To Hydrogen Sulfide
Positive Regulation Of Type 2 Mitophagy
Cellular Response To L-glutamate
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Cytoskeleton-dependent Intracellular Transport
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Synapse Organization
Spindle Assembly
Cell Division
Odontoblast Differentiation
Pathways
PINK1-PRKN Mediated Mitophagy
Regulation of necroptotic cell death
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Neutrophil degranulation
AURKA Activation by TPX2
Potential therapeutics for SARS
Drugs
Vinorelbine
Vincristine
Vinblastine
Podofilox
Colchicine
Epothilone D
Patupilone
CYT997
CA4P
ZEN-012
Tirbanibulin
Copper
Artenimol
Vinflunine
Depatuxizumab mafodotin
Milataxel
Colchiceine
Diseases
Parkinson's disease (PD)
GWAS
Triglyceride levels in HIV infection (
33109212
)
Autism spectrum disorder or schizophrenia (
28540026
)
Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) (
30958311
)
Handedness (non-right-handed vs right-handed) (
31504236
)
Left-handedness (
32989287
)
Left–right brain asymmetry (
33723403
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
131 interacting genes:
ADRM1
AIMP2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCND1
CDKN1A
CHPF
COMMD1
COXFA4L2
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EIF4B
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GATA4
GCK
GPR37
GRIN2B
GTPBP4
HDAC6
HEXD
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
MTOR
NEDD8
NEK2
NKRF
NQO1
PA2G4
PAFAH1B2
PDCD2
PHB2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RFFL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
SRSF1
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
VDR
YWHAH
ZNF622
ZNF746
84 interacting genes:
ADAP2
ALDOA
APP
ARL8B
ATXN3
B4GALT1
BCL2L13
BMPR2
BRCA1
CDK1
CDKN2A
CLIP1
CMTM5
CNN1
CREBBP
CRIPT
DISC1
DPYSL2
DUX4
DYNLL1
EML4
ESR1
FXR1
GDAP1
GRM1
HDAC6
HGS
HTRA2
HTT
LINC01554
LNX2
MAGEA2B
MAL2
MAP1A
MAP3K10
MAP4
MAP6
MAPRE1
MAPT
MARK4
MRGBP
MTNR1A
MX1
NCALD
NCAM1
NCAPH2
NDEL1
NPHP1
OGT
PFDN4
PLK1
PRKN
PRMT1
PTEN
RAB8B
RACK1
RASSF1
RSPH1
S100A8
S100A9
SDC3
SPP1
STAU1
SUMO2
SYT9
TAOK2
TBCD
TBKBP1
TGM2
TINF2
TPPP
TTBK1
TTK
TUBA1A
UBE3A
USP25
VAV1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
ZFYVE21
ZMYND19
Entrez ID
5071
203068
HPRD ID
03967
01852
Ensembl ID
ENSG00000185345
ENSG00000196230
Uniprot IDs
O60260
X5DR79
B4DMJ5
B4DQN9
B4DY90
P07437
Q5ST81
Q5SU16
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
8IK6
8IKV
8JWV
8WZN
8WZO
3QNZ
3QO0
5N5N
6I2I
6QUS
6QUY
6QVE
6QVJ
7TRG
7TTN
7TTT
7TUB
7X0S
8BPO
8T42
8U3Z
8V2J
9BP6
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Macromolecule Catabolic Process
Cytosol
Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Proteolysis
Nucleus
Protein K48-linked Ubiquitination
Catabolic Process
Protein Modification Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Ubiquitin-like Protein Transferase Activity
Regulation Of Metabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Nucleoplasm
Mitochondrial Outer Membrane
Regulation Of Protein Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Proteolysis
Cytoplasm
Ubiquitin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
ATP Binding
Regulation Of Post-translational Protein Modification
Regulation Of Mitophagy
Transferase Activity
Protein Binding
Regulation Of Autophagy Of Mitochondrion
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Microtubule-based Process
Microtubule Cytoskeleton Organization
Organelle Organization
Microtubule Binding
Microtubule
Regulation Of Cellular Component Organization
Cytoskeleton Organization
Microtubule Polymerization
Tubulin Binding
Identical Protein Binding
Microtubule Cytoskeleton
Microtubule Associated Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Microtubule Polymerization Or Depolymerization
Cytoskeleton
Cytosol
Neuron Projection
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Beta-tubulin Binding
Regulation Of Organelle Organization
Cytoplasm
Cytoskeleton-dependent Intracellular Transport
Protein Polymerization
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Proteolysis
Axon
Protein Localization To Organelle
Transport Along Microtubule
Regulation Of Protein Localization
Supramolecular Fiber Organization
Positive Regulation Of Cellular Component Organization
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Regulation Of Growth
Regulation Of Cellular Response To Stress
Apoptotic Process
Dendrite
Alpha-tubulin Binding
Regulation Of Microtubule-based Process
Tau Protein Binding
Synapse
Programmed Cell Death
Cell Death
Microtubule-based Transport
Regulation Of Microtubule Cytoskeleton Organization
Axo-dendritic Transport
Regulation Of Intracellular Signal Transduction
Cilium Disassembly
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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