PRKN and SRSF1

Number of citations of the paper that reports this interaction (PubMedID 36508830)
0

Data Source:
BioGRID (pull down)

		PRKN	SRSF1
Description		parkin RBR E3 ubiquitin protein ligase	serine and arginine rich splicing factor 1
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GO Annotations	Cellular Component	Golgi Membrane Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Postsynaptic Density Membrane Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Axon Synaptic Vesicle Membrane Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Lewy Body Intracellular Vesicle Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Nuclear Envelope Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding Transferase Activity SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding DNA Topoisomerase Binding RS Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Synaptic Transmission, Dopaminergic Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Autophagy Response To Oxidative Stress Response To Unfolded Protein Mitochondrion Organization Central Nervous System Development Learning Locomotory Behavior Adult Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Response To Muscle Activity Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Anatomical Structure Morphogenesis Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Oxidative Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein K27-linked Ubiquitination Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Protein Stabilization Response To Corticosterone Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Localization Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Necroptotic Process Regulation Of Canonical Wnt Signaling Pathway Type 2 Mitophagy Regulation Of Biological Quality Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Negative Regulation Of Excitatory Postsynaptic Potential Cellular Response To Toxic Substance Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Protein Catabolic Process At Presynapse Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Secretion By Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Cellular Response To L-glutamine Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Cellular Response To L-glutamate Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing RNA Splicing Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of RNA Splicing Protein Localization To Nucleus Regulation Of RNA Splicing MRNA Stabilization Oligodendrocyte Differentiation MRNA Transport Cardiac Muscle Contraction Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Liver Regeneration Protein Localization To P-body
Pathways		PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs			Copper
Diseases		Parkinson's disease (PD)
GWAS		Triglyceride levels in HIV infection ( 33109212)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		131 interacting genes: ADRM1 AIMP2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCND1 CDKN1A CHPF COMMD1 COXFA4L2 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EIF4B EPS15 FAF1 FAM120A FBP1 FBXO7 FBXW7 GATA4 GCK GPR37 GRIN2B GTPBP4 HDAC6 HEXD IKBKG LSG1 MDM2 MEOX1 MEOX2 MFN1 MFN2 MRPL13 MRPL19 MRPL45 MTOR NEDD8 NEK2 NKRF NQO1 PA2G4 PAFAH1B2 PDCD2 PHB2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RALY RANBP2 RBCK1 REL RFFL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SF3B2 SF3B3 SIM2 SNCA SNCAIP SRSF1 STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z USP30 USP33 VDAC1 VDR YWHAH ZNF622 ZNF746	53 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK13 CDK6 CDR1 CLK1 CLK2 CLK3 CLK4 CPSF7 DANCR DIDO1 DYRK1A FOXP1 GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L LUC7L3 NFYA NXF1 PPARG PRKN PRMT1 PRP4K PRPF4 PSIP1 RNF10 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		5071	6426
HPRD ID		03967	02887
Ensembl ID		ENSG00000185345	ENSG00000136450
Uniprot IDs		O60260 X5DR79	Q07955 Q59FA2
PDB IDs		1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13 8IK6 8IKV 8JWV 8WZN 8WZO	1X4A 2M7S 2M8D 2O3D 3BEG 4C0O 6HPJ 7ABG 8QO9
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Macromolecule Catabolic Process Cytosol Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Nucleus Protein K48-linked Ubiquitination Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Nucleotide Binding Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Regulation Of Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Nucleoplasm Mitochondrial Outer Membrane Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Proteolysis Cytoplasm Ubiquitin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Mitophagy Transferase Activity Protein Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process	MRNA Metabolic Process RNA Splicing MRNA Processing Nuclear Speck RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleus Protein-RNA Complex Assembly RNA Binding RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Protein Serine/threonine Kinase Activity MRNA Splicing, Via Spliceosome Protein Serine Kinase Activity MRNA Splice Site Recognition Nucleic Acid Binding Protein-containing Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex MRNA Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-containing Complex Organization Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Gene Expression U2-type Prespliceosome Regulation Of Macromolecule Biosynthetic Process Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Protein Tyrosine Kinase Activity Identical Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
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