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PRKN and GTPBP4
Number of citations of the paper that reports this interaction (PubMedID
33305682
)
68
Data Source:
BioGRID
(unspecified method, affinity chromatography technology)
PRKN
GTPBP4
Description
parkin RBR E3 ubiquitin protein ligase
GTP binding protein 4
Image
GO Annotations
Cellular Component
Golgi Membrane
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Synaptic Vesicle
Postsynaptic Density
Membrane
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Axon
Synaptic Vesicle Membrane
Protein-containing Complex
Cell Projection
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Synapse
Perinuclear Region Of Cytoplasm
Lewy Body
Intracellular Vesicle
Dopaminergic Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Membrane
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Nucleotide Binding
RNA Binding
GTPase Activity
Protein Binding
GTP Binding
Preribosome Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Synaptic Transmission, Dopaminergic
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Autophagy
Response To Oxidative Stress
Response To Unfolded Protein
Mitochondrion Organization
Central Nervous System Development
Learning
Locomotory Behavior
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Positive Regulation Of Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Response To Muscle Activity
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Anatomical Structure Morphogenesis
Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Oxidative Stress
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Protein K27-linked Ubiquitination
Host-mediated Suppression Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Regulation Of Neurotransmitter Secretion
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Response To Corticosterone
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Mitochondrion Localization
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Necroptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Type 2 Mitophagy
Regulation Of Biological Quality
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Negative Regulation Of Excitatory Postsynaptic Potential
Cellular Response To Toxic Substance
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Mitochondrion To Lysosome Vesicle-mediated Transport
Regulation Protein Catabolic Process At Presynapse
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Mitophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Secretion By Cell
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Response To Curcumin
Cellular Response To L-glutamine
Cellular Response To Hydrogen Sulfide
Positive Regulation Of Type 2 Mitophagy
Cellular Response To L-glutamate
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Osteoblast Differentiation
Negative Regulation Of DNA Replication
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Negative Regulation Of Protein Ubiquitination
Ribosome Biogenesis
Ribosomal Large Subunit Biogenesis
Protein Stabilization
Pathways
PINK1-PRKN Mediated Mitophagy
Regulation of necroptotic cell death
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Triglyceride levels in HIV infection (
33109212
)
Height (
28552196
)
Interacting Genes
131 interacting genes:
ADRM1
AIMP2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCND1
CDKN1A
CHPF
COMMD1
COXFA4L2
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EIF4B
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GATA4
GCK
GPR37
GRIN2B
GTPBP4
HDAC6
HEXD
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
MTOR
NEDD8
NEK2
NKRF
NQO1
PA2G4
PAFAH1B2
PDCD2
PHB2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RFFL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
SRSF1
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
VDR
YWHAH
ZNF622
ZNF746
8 interacting genes:
COPB1
GGA1
GGA2
GGA3
PRKN
SRPK2
USP7
YWHAG
Entrez ID
5071
23560
HPRD ID
03967
09976
Ensembl ID
ENSG00000185345
ENSG00000107937
Uniprot IDs
O60260
X5DR79
D2CFK9
Q9BZE4
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
8IK6
8IKV
8JWV
8WZN
8WZO
6LSS
6LU8
8FKP
8FKQ
8FKR
8FKS
8FKT
8FKU
8FKV
8FKW
8FKX
8FKY
8FKZ
8FL0
8FL2
8FL3
8FL4
8FL6
8FL7
8FL9
8FLA
8FLB
8FLC
8FLD
8FLE
8FLF
8IDT
8IDY
8IE3
8INE
8INF
8INK
8IPD
8IPX
8IPY
8IR1
8IR3
8RL2
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Macromolecule Catabolic Process
Cytosol
Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Proteolysis
Nucleus
Protein K48-linked Ubiquitination
Catabolic Process
Protein Modification Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Ubiquitin-like Protein Transferase Activity
Regulation Of Metabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Nucleoplasm
Mitochondrial Outer Membrane
Regulation Of Protein Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Proteolysis
Cytoplasm
Ubiquitin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
ATP Binding
Regulation Of Post-translational Protein Modification
Regulation Of Mitophagy
Transferase Activity
Protein Binding
Regulation Of Autophagy Of Mitochondrion
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Ubiquitin Binding
Protein Localization To Cell Surface
Golgi To Plasma Membrane Protein Transport
Establishment Of Protein Localization To Plasma Membrane
Golgi To Plasma Membrane Transport
Regulation Of Retrograde Transport, Endosome To Golgi
Golgi Vesicle Transport
Post-Golgi Vesicle-mediated Transport
Phosphatidylinositol Binding
Regulation Of Protein Stability
Regulation Of Protein Catabolic Process
Vesicle-mediated Transport To The Plasma Membrane
Protein K6-linked Ubiquitination
Intracellular Protein Localization
Intracellular Protein Transport
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Catabolic Process
Protein Localization To Plasma Membrane
Early Endosome Membrane
Establishment Of Protein Localization To Membrane
Trans-Golgi Network
Vesicle-mediated Transport
Intracellular Transport
Presynapse
Protein Stabilization
Protein Catabolic Process
Protein Localization To Cell Periphery
Protein Localization To Organelle
Establishment Of Protein Localization
Golgi Apparatus
Protein Destabilization
Protein Localization To Lysosome
Endosome Membrane
Small GTPase Binding
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Prostaglandin F Receptor Activity
TORC1 Signaling
Protein Localization To Membrane
Protein-containing Complex
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Protein Metabolic Process
Cellular Localization
Positive Regulation Of Metabolic Process
Negative Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Establishment Of Localization In Cell
Interleukin-2 Receptor Complex
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Linear Polyubiquitination
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Tagcloud (Intersection)
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