PRKN and SF3B2

Number of citations of the paper that reports this interaction (PubMedID 35256949)
73

Data Source:
BioGRID (unspecified method, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)

		PRKN	SF3B2
Description		parkin RBR E3 ubiquitin protein ligase	splicing factor 3b subunit 2
Image
GO Annotations	Cellular Component	Golgi Membrane Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Postsynaptic Density Membrane Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Axon Synaptic Vesicle Membrane Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Lewy Body Intracellular Vesicle Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding Transferase Activity SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Synaptic Transmission, Dopaminergic Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Autophagy Response To Oxidative Stress Response To Unfolded Protein Mitochondrion Organization Central Nervous System Development Learning Locomotory Behavior Adult Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Response To Muscle Activity Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Anatomical Structure Morphogenesis Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Oxidative Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Protein K27-linked Ubiquitination Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Protein Stabilization Response To Corticosterone Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Localization Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Necroptotic Process Regulation Of Canonical Wnt Signaling Pathway Type 2 Mitophagy Regulation Of Biological Quality Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Negative Regulation Of Excitatory Postsynaptic Potential Cellular Response To Toxic Substance Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Protein Catabolic Process At Presynapse Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Secretion By Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Cellular Response To L-glutamine Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Cellular Response To L-glutamate Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly
Pathways		PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Triglyceride levels in HIV infection ( 33109212)	Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels ( 23823483)
Interacting Genes		131 interacting genes: ADRM1 AIMP2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCND1 CDKN1A CHPF COMMD1 COXFA4L2 CRX CUL1 DLG1 DLX2 DNM1L DYRK1A EIF4B EPS15 FAF1 FAM120A FBP1 FBXO7 FBXW7 GATA4 GCK GPR37 GRIN2B GTPBP4 HDAC6 HEXD IKBKG LSG1 MDM2 MEOX1 MEOX2 MFN1 MFN2 MRPL13 MRPL19 MRPL45 MTOR NEDD8 NEK2 NKRF NQO1 PA2G4 PAFAH1B2 PDCD2 PHB2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RALY RANBP2 RBCK1 REL RFFL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SF3B2 SF3B3 SIM2 SNCA SNCAIP SRSF1 STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z USP30 USP33 VDAC1 VDR YWHAH ZNF622 ZNF746	106 interacting genes: AKAP9 APBB1 APP C7orf25 C8orf33 CASK CSNK2A1 ECPAS ERG FMR1 FRA10AC1 FXR1 FXR2 HNRNPC KDM1A LSM2 LSM3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PCBP2 PRC1 PRKN PRPF40A RBM10 RBM11 RBM7 RBM8A RNF10 SF3B4 SMAD3 SUMO2 TCERG1 THOC1 TOE1 TTC14 U2AF1 USP7 WBP4 ZCCHC10
Entrez ID		5071	10992
HPRD ID		03967	10410
Ensembl ID		ENSG00000185345	ENSG00000087365
Uniprot IDs		O60260 X5DR79	Q13435
PDB IDs		1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13 8IK6 8IKV 8JWV 8WZN 8WZO	2DO5 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7DVQ 7EVO 7ONB 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Macromolecule Catabolic Process Cytosol Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Nucleus Protein K48-linked Ubiquitination Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Nucleotide Binding Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Regulation Of Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Nucleoplasm Mitochondrial Outer Membrane Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Proteolysis Cytoplasm Ubiquitin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process ATP Binding Regulation Of Post-translational Protein Modification Regulation Of Mitophagy Transferase Activity Protein Binding Regulation Of Autophagy Of Mitochondrion Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication
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