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PRKN and UBB
Number of citations of the paper that reports this interaction (PubMedID
29995846
)
44
Data Source:
BioGRID
(x-ray crystallography)
HPRD
(in vitro)
PRKN
UBB
Description
parkin RBR E3 ubiquitin protein ligase
ubiquitin B
Image
GO Annotations
Cellular Component
Golgi Membrane
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Synaptic Vesicle
Postsynaptic Density
Membrane
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Axon
Synaptic Vesicle Membrane
Protein-containing Complex
Cell Projection
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Synapse
Perinuclear Region Of Cytoplasm
Lewy Body
Intracellular Vesicle
Dopaminergic Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Endocytic Vesicle Membrane
Vesicle
Neuron Projection
Neuronal Cell Body
Extracellular Exosome
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Synaptic Transmission, Dopaminergic
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Autophagy
Response To Oxidative Stress
Response To Unfolded Protein
Mitochondrion Organization
Central Nervous System Development
Learning
Locomotory Behavior
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Positive Regulation Of Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Response To Muscle Activity
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Anatomical Structure Morphogenesis
Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Oxidative Stress
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Protein K27-linked Ubiquitination
Host-mediated Suppression Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Regulation Of Neurotransmitter Secretion
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Response To Corticosterone
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Mitochondrion Localization
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Necroptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Type 2 Mitophagy
Regulation Of Biological Quality
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Negative Regulation Of Excitatory Postsynaptic Potential
Cellular Response To Toxic Substance
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Mitochondrion To Lysosome Vesicle-mediated Transport
Regulation Protein Catabolic Process At Presynapse
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Mitophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Secretion By Cell
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Response To Curcumin
Cellular Response To L-glutamine
Cellular Response To Hydrogen Sulfide
Positive Regulation Of Type 2 Mitophagy
Cellular Response To L-glutamate
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Male Meiosis I
Female Meiosis I
Male Gonad Development
Female Gonad Development
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Hypothalamus Gonadotrophin-releasing Hormone Neuron Development
Positive Regulation Of Protein Ubiquitination
Regulation Of Neuron Apoptotic Process
Mitochondrion Transport Along Microtubule
Neuron Projection Morphogenesis
Regulation Of Mitochondrial Membrane Potential
Adipose Tissue Development
Fat Pad Development
Regulation Of Proteasomal Protein Catabolic Process
Seminiferous Tubule Development
Energy Homeostasis
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Monoubiquitination
Pathways
PINK1-PRKN Mediated Mitophagy
Regulation of necroptotic cell death
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
VLDLR internalisation and degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Interferon alpha/beta signaling
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Signaling by CSF1 (M-CSF) in myeloid cells
Maturation of protein E
SARS-CoV-1 activates/modulates innate immune responses
Maturation of protein E
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Regulation of BACH1 activity
Signaling by ALK fusions and activated point mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
KEAP1-NFE2L2 pathway
Regulation of NF-kappa B signaling
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Amyloid fiber formation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
Regulation of pyruvate metabolism
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
PD-L1(CD274) glycosylation and translocation to plasma membrane
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
(4s)-5-Fluoro-L-Leucine
Diseases
Parkinson's disease (PD)
GWAS
Triglyceride levels in HIV infection (
33109212
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Interacting Genes
131 interacting genes:
ADRM1
AIMP2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCND1
CDKN1A
CHPF
COMMD1
COXFA4L2
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EIF4B
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GATA4
GCK
GPR37
GRIN2B
GTPBP4
HDAC6
HEXD
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
MTOR
NEDD8
NEK2
NKRF
NQO1
PA2G4
PAFAH1B2
PDCD2
PHB2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RFFL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
SRSF1
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
VDR
YWHAH
ZNF622
ZNF746
81 interacting genes:
APP
ATXN3
BIRC2
BRAP
BRCA1
CDC25A
CDC34
CDIP1
CDKN1B
CDT1
CDX2
CHEK1
DAZAP2
DESI1
DNMT1
DUSP1
ECT2
EGFR
ELF4
EPS15
ERBB2
FAM168A
FANCD2
FSHR
HDAC6
HGS
HLA-A
IKBKB
IKBKG
JUN
LIG4
LYN
MAPT
MDM2
MTURN
MYBL2
MYC
NR3C1
NTRK1
NTRK2
OPTN
PCNA
PIN1
PLEKHB2
PLSCR4
POLI
PRKN
PSMD4
RABGEF1
RAD23A
RAD23B
RNF11
SDCBP
SH3KBP1
SKP2
SMAD4
SMURF1
SNCA
SNCAIP
SQSTM1
STUB1
SYK
TAX1BP1
TGFBR1
TP53
TRAF6
TRIM37
TRIM5
UBASH3A
UBASH3B
UBE2N
UBE2S
UBQLN1
UBQLN2
UCHL1
UIMC1
USP1
USP30
WEE2-AS1
WWOX
XIAP
Entrez ID
5071
7314
HPRD ID
03967
06771
Ensembl ID
ENSG00000185345
ENSG00000170315
Uniprot IDs
O60260
X5DR79
P0CG47
Q5U5U6
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
8IK6
8IKV
8JWV
8WZN
8WZO
2KHW
2MBB
2MRO
2MSG
2N13
4UEL
4UF6
4WHV
4WLR
4WUR
4XOF
4ZFR
4ZFT
4ZPZ
4ZUX
5BNB
5CAW
5CRA
5CVM
5CVN
5CVO
5D0K
5D0M
5DFL
5DK8
5E6J
5EDV
5EMZ
5EYA
5GJQ
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5H7S
5IBK
5IFR
5JBY
5JG6
5JP3
5JTJ
5JTV
5K9P
5KGF
5KHY
5KYC
5KYD
5KYE
5KYF
5L8H
5L8W
5L9T
5LN1
5LRV
5LRW
5LRX
5M93
5MNJ
5N2W
5N38
5NL5
5NLJ
5NVG
5O44
5O6T
5OHK
5OHL
5OHN
5OHP
5TOF
5TOG
5TUT
5TXK
5UJL
5UJN
5ULF
5ULH
5ULK
5V1Y
5V1Z
5VEY
5VF0
5VNZ
5VO0
5VZM
5VZW
5W46
5WFI
5X3M
5X3N
5X3O
5XBO
5XDP
5XK4
5XK5
5XPK
5YDR
5YIJ
5YIK
5YMY
5YT6
5ZBU
5ZD0
6ASR
6BVA
6BYH
6C16
6CP2
6DGF
6EI1
6FDK
6FGE
6FTX
6FX4
6FYH
6GLC
6GZS
6H4H
6HEI
6HEK
6IF1
6ISU
6JB6
6JB7
6JMA
6K4I
6K9P
6KOW
6KOX
6LP2
6MSB
6MSD
6MSE
6MSG
6N13
6NJ9
6NJG
6O96
6OAM
6PGV
6PZV
6QF8
6QK9
6QML
6TBM
6UH5
6XAA
6XQC
6XZ1
7AY2
7BBD
7BU0
7CAP
7DNI
7DNJ
7E8I
7F7X
7JMS
7LYC
7M2K
7MC9
7MEY
7MYF
7MYH
7NBB
7NPO
7OJE
7OJX
7QO4
7QO5
7RBR
7RMA
7UD5
7US1
7UV5
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
7W3U
7W54
7XCR
7XCT
7YQK
8A67
8BS9
8C07
8C61
8CMR
8DMQ
8DMS
8DU4
8EFW
8EFX
8EHO
8G6G
8G6H
8G6Q
8G6S
8GRM
8H1T
8HQY
8IC9
8ITP
8J1P
8K0G
8OYP
8PP6
8Q00
8RQI
8SN3
8SN4
8SN5
8SN6
8SN7
8SN8
8SN9
8SNA
8T2D
8TXV
8TXW
8TXX
8V25
8V26
8V27
8V28
8W31
8WG5
8XEP
9AVT
9AVW
9AZJ
9B0Z
9B12
9C5E
9EMK
9HNW
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Macromolecule Catabolic Process
Cytosol
Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Proteolysis
Nucleus
Protein K48-linked Ubiquitination
Catabolic Process
Protein Modification Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Ubiquitin-like Protein Transferase Activity
Regulation Of Metabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Nucleoplasm
Mitochondrial Outer Membrane
Regulation Of Protein Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Proteolysis
Cytoplasm
Ubiquitin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
ATP Binding
Regulation Of Post-translational Protein Modification
Regulation Of Mitophagy
Transferase Activity
Protein Binding
Regulation Of Autophagy Of Mitochondrion
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Response To Stress
Negative Regulation Of Signal Transduction
Identical Protein Binding
Intracellular Signal Transduction
Cellular Response To Stress
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Modification Process
Protein Polyubiquitination
Regulation Of Cellular Response To Stress
Post-translational Protein Modification
Protein-containing Complex
Regulation Of Apoptotic Process
Nucleus
Ubiquitin-dependent Protein Catabolic Process
Polyubiquitin Modification-dependent Protein Binding
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Programmed Cell Death
Enzyme Binding
Positive Regulation Of Intracellular Signal Transduction
DNA Damage Response
Positive Regulation Of Signaling
Regulation Of Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Ubiquitin Binding
Cytosol
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Ubiquitination
Positive Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Ubiquitin-protein Transferase Activity
Regulation Of Protein Catabolic Process
Regulation Of MAPK Cascade
Negative Regulation Of Intracellular Signal Transduction
Protein Modification By Small Protein Conjugation
Nucleoplasm
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