HIST2H4A and TBL1X

Number of citations of the paper that reports this interaction (PMID 12628926)
122

Data Source:
HPRD (in vivo, in vitro)

		HIST2H4A	TBL1X
Gene Name		histone cluster 2, H4a	transducin (beta)-like 1X-linked
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Proteolysis Notch Signaling Pathway Sensory Perception Of Sound Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		27 interactors: ATAD2 BRD4 BRDT DNMT3L EP300 HAT1 HIST1H3A HIST2H2AC KAT2A KAT5 LBR NAP1L4 PRMT1 PTMA RAD51B RBBP4 RNF20 RPS6KA5 SET TAF15 TBL1X TBL1XR1 TP53BP1 UBC UCHL5 UHRF1 YWHAQ	25 interactors: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 GPS2 HDAC3 HIST1H4A HIST2H2AA3 HIST2H2BE HIST2H3C HIST2H4A HP HR KHDRBS1 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1
Entrez ID		8370	6907
HPRD ID		11821	02183
Ensembl ID		ENSG00000183941	ENSG00000101849
Uniprot IDs		B2R4R0 P62805	O60907
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA	2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Transcription, DNA-templated Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Biosynthetic Process Protein Acetylation Nucleosome Organization Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cellular Metabolic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Assembly Histone H4 Acetylation Peptidyl-lysine Modification DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Positive Regulation Of Metabolic Process	Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Nucleobase-containing Compound Metabolic Process Lung Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Notch Signaling Pathway DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Telomere Maintenance Gene Expression Regulation Of Chromosome Organization Chromatin Modification Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Female Courtship Behavior DNA-templated Transcription, Initiation Organelle Organization Negative Regulation Of JNK Cascade Histone H4-K20 Demethylation Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Stress-activated MAPK Cascade Chromatin Silencing Transcription, DNA-templated Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Macromolecule Biosynthetic Process Lung Epithelial Cell Differentiation
Tagcloud ?			c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1
Tagcloud (Difference) ?			c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1
Tagcloud (Intersection) ?