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HIST2H4A and PTMA
Number of citations of the paper that reports this interaction (PMID
8814229
)
9
Data Source:
HPRD
(two hybrid, in vitro)
HIST2H4A
PTMA
Gene Name
histone cluster 2, H4a
prothymosin, alpha
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Protein Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Transcription, DNA-templated
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Protein-Protein Interactions
27 interactors:
ATAD2
BRD4
BRDT
DNMT3L
EP300
HAT1
HIST1H3A
HIST2H2AC
KAT2A
KAT5
LBR
NAP1L4
PRMT1
PTMA
RAD51B
RBBP4
RNF20
RPS6KA5
SET
TAF15
TBL1X
TBL1XR1
TP53BP1
UBC
UCHL5
UHRF1
YWHAQ
41 interactors:
CASP3
CASP7
CCNA2
CCNB1
CDK1
CDK2
CDK4
CREBBP
EP300
ESR1
HDAC1
HDAC2
HIST1H1A
HIST1H2AJ
HIST1H2BG
HIST1H4A
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H3
HSPA1A
IL7R
KEAP1
KPNA2
KPNB1
NCOR1
NUP62
NUPR1
NUTF2
PCNA
PHB2
RAN
RCC1
SET
SIN3A
STAT3
TERF1
TERF2
TERF2IP
VIPR1
ZDHHC17
Entrez ID
8370
5757
HPRD ID
11821
01778
Ensembl ID
ENSG00000183941
ENSG00000187514
Uniprot IDs
B2R4R0
P62805
P06454
Q53S24
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
2L9I
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription, DNA-templated
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
RNA Biosynthetic Process
Protein Acetylation
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
DNA Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Positive Regulation Of Cellular Metabolic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Assembly
Histone H4 Acetylation
Peptidyl-lysine Modification
DNA Methylation On Cytosine
Chromatin Assembly Or Disassembly
Positive Regulation Of Metabolic Process
Chromosome Organization
Chromatin Organization
Organelle Organization
DNA Metabolic Process
Chromatin Modification
Mitotic Cell Cycle
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cell Cycle
Regulation Of Nitrogen Compound Metabolic Process
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Histone Modification
DNA Packaging
Regulation Of Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Cell Cycle
Negative Regulation Of Gene Expression, Epigenetic
Response To Organic Substance
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Proliferation
Protein Complex Assembly
Response To Stimulus
Mitotic Cell Cycle Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
DNA Replication
Viral Process
DNA Conformation Change
Negative Regulation Of Biosynthetic Process
Homeostatic Process
Regulation Of Protein Metabolic Process
Rhythmic Process
Regulation Of Chromosome Organization
G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Stimulus
Nucleosome Assembly
Regulation Of RNA Metabolic Process
Cell Cycle Process
Cellular Response To Stress
Regulation Of Cell Death
Chromatin Assembly
Tagcloud
?
adjacent
advanced
ajcc
assessment
colon
crc
depth
dfs
distant
help
hence
invasion
lnm
lymph
metastasis
mutant
node
os
overexpression
plays
predict
prognosis
prothymosin
survival
tissue
tp53
translational
triggers
tumorigenesis
Tagcloud (Difference)
?
adjacent
advanced
ajcc
assessment
colon
crc
depth
dfs
distant
help
hence
invasion
lnm
lymph
metastasis
mutant
node
os
overexpression
plays
predict
prognosis
prothymosin
survival
tissue
tp53
translational
triggers
tumorigenesis
Tagcloud (Intersection)
?