HIST2H4A and DNMT3L

Number of citations of the paper that reports this interaction (PMID 17687327)
307

Data Source:
BioGRID (pull down)

		HIST2H4A	DNMT3L
Gene Name		histone cluster 2, H4a	DNA (cytosine-5-)-methyltransferase 3-like
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Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Cytosol
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Epigenetic regulation of gene expression DNA methylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATAD2 BRD4 BRDT DNMT3L EP300 HAT1 HIST1H3A HIST2H2AC KAT2A KAT5 LBR NAP1L4 PRMT1 PTMA RAD51B RBBP4 RNF20 RPS6KA5 SET TAF15 TBL1X TBL1XR1 TP53BP1 UBC UCHL5 UHRF1 YWHAQ	11 interactors: DNMT3A DNMT3B GSK3B HDAC1 HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A NUDT21 PHPT1 RSL24D1
Entrez ID		8370	29947
HPRD ID		11821	09417
Ensembl ID		ENSG00000183941	ENSG00000142182
Uniprot IDs		B2R4R0 P62805	Q9UJW3
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA	2PV0 2PVC 2QRV
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Transcription, DNA-templated Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Biosynthetic Process Protein Acetylation Nucleosome Organization Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cellular Metabolic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Assembly Histone H4 Acetylation Peptidyl-lysine Modification DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Positive Regulation Of Metabolic Process	DNA Methylation On Cytosine Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Silencing DNA Methylation DNA Modification Gene Silencing Regulation Of Gene Expression By Genetic Imprinting Genetic Imprinting S-adenosylmethioninamine Metabolic Process Hypermethylation Of CpG Island DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Methylation-dependent Chromatin Silencing Chromatin Organization Negative Regulation Of Biosynthetic Process Chromatin Silencing At RDNA Methylation Regulation Of DNA Methylation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Amino Acid Stimulus ATP-dependent Chromatin Remodeling Peptidyl-histidine Dephosphorylation Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development DNA Metabolic Process Response To Amino Acid Re-entry Into Mitotic Cell Cycle Histone H4-K20 Demethylation Negative Regulation Of ATP Citrate Synthase Activity Negative Regulation Of Neuron Maturation Nucleosome Assembly Nucleobase-containing Compound Metabolic Process Chromatin Assembly Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Nucleosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Megakaryocyte Differentiation Cellular Response To Interleukin-3 Protein-DNA Complex Assembly
Tagcloud ?			add adds atrx autoinhibition autoinhibitory catalytically connection disrupts embryogenesis enzymatic h3k4 h3k4me0 h3k4me3 imprinting inheritance methyltransferase methyltransferases novo paralogue positioning recognizes releases stimulates tail unexpected unmethylated
Tagcloud (Difference) ?			add adds atrx autoinhibition autoinhibitory catalytically connection disrupts embryogenesis enzymatic h3k4 h3k4me0 h3k4me3 imprinting inheritance methyltransferase methyltransferases novo paralogue positioning recognizes releases stimulates tail unexpected unmethylated
Tagcloud (Intersection) ?