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HIST2H4A and RPS6KA5
Number of citations of the paper that reports this interaction (PMID
15010469
)
10
Data Source:
BioGRID
(enzymatic study)
HIST2H4A
RPS6KA5
Gene Name
histone cluster 2, H4a
ribosomal protein S6 kinase, 90kDa, polypeptide 5
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Histone Phosphorylation
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Histone Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Histone H3-S10 Phosphorylation
Histone H3-S28 Phosphorylation
Histone H2A-S1 Phosphorylation
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
CREB phosphorylation
Axon guidance
Toll Like Receptor 7/8 (TLR7/8) Cascade
CREB phosphorylation
L1CAM interactions
Recycling pathway of L1
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
NCAM signaling for neurite out-growth
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
ERK/MAPK targets
Toll Like Receptor 3 (TLR3) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Bone mineral density (
22504420
)
Protein-Protein Interactions
27 interactors:
ATAD2
BRD4
BRDT
DNMT3L
EP300
HAT1
HIST1H3A
HIST2H2AC
KAT2A
KAT5
LBR
NAP1L4
PRMT1
PTMA
RAD51B
RBBP4
RNF20
RPS6KA5
SET
TAF15
TBL1X
TBL1XR1
TP53BP1
UBC
UCHL5
UHRF1
YWHAQ
59 interactors:
ACTG1
AKT1S1
ALG8
APP
ATF1
ATF2
BAD
CEBPB
CREB1
CREBBP
CRMP1
CSNK2B
DDAH2
DNAJC11
EIF4E
EIF4EBP1
EP300
ERH
ETV1
EZH2
FN1
GPRASP2
HIST1H1B
HIST1H3E
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H2A
HIST3H2BB
HIST3H3
HIST4H4
HMGN1
HSPB1
HSPB2
IL17RB
ITSN1
MAPK11
MAPK14
MAPT
MBP
MDFIC
NR4A1
PDLIM1
PLA2G4A
RAI1
RELA
RNF19A
ROBO2
RPA1
SMAD6
SMARCB1
STAT1
STAT3
STK11
TH
TXNDC11
UNC119
ZAK
ZNF775
Entrez ID
8370
9252
HPRD ID
11821
06789
Ensembl ID
ENSG00000183941
ENSG00000100784
Uniprot IDs
B2R4R0
P62805
B7Z2Y5
O75582
Q9UG98
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
1VZO
3KN5
3KN6
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription, DNA-templated
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
RNA Biosynthetic Process
Protein Acetylation
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
DNA Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Positive Regulation Of Cellular Metabolic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Assembly
Histone H4 Acetylation
Peptidyl-lysine Modification
DNA Methylation On Cytosine
Chromatin Assembly Or Disassembly
Positive Regulation Of Metabolic Process
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Defense Response
Enzyme Linked Receptor Protein Signaling Pathway
Response To Abiotic Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Organic Substance
Cellular Response To Stress
Neurotrophin Signaling Pathway
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Cell Differentiation
Innate Immune Response
Immune Response
Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
System Development
Regulation Of Cell Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Developmental Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Anatomical Structure Development
Response To Hormone
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Multicellular Organismal Development
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Immune System Process
Chromatin Organization
Chromosome Organization
Generation Of Neurons
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Immune Response-regulating Signaling Pathway
Stress-activated MAPK Cascade
MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud
?
27a
5p
arrays
bioinformatics
cbl
changed
creb
creb1
directive
erk2
escc
esophageal
folds
grb2
mapk1
mapk14
microrna
mir
mirna
mirnas
ngfr
options
prediction
pt1n0
sos1
sprouty
spry2
taqman
verify
Tagcloud (Difference)
?
27a
5p
arrays
bioinformatics
cbl
changed
creb
creb1
directive
erk2
escc
esophageal
folds
grb2
mapk1
mapk14
microrna
mir
mirna
mirnas
ngfr
options
prediction
pt1n0
sos1
sprouty
spry2
taqman
verify
Tagcloud (Intersection)
?